NP_001161051.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,937 Da
NCBI Official Full Name
sodium-dependent phosphate transport protein 2A isoform 2
NCBI Official Synonym Full Names
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
NCBI Official Synonym Symbols
NPT2; FRTS2; SLC11; NAPI-3; NPTIIa; NPHLOP1; SLC17A2 [Similar Products]
NCBI Protein Information
sodium-dependent phosphate transport protein 2A; naPi-2a; Na(+)/Pi cotransporter 2A; sodium/phosphate co-transporter; sodium/phosphate cotransporter 2A; solute carrier family 34 member 1; Na+-phosphate cotransporter type II; sodium-phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; renal sodium-dependent phosphate transporter; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 34 (sodium phosphate), member 1
UniProt Protein Name
Sodium-dependent phosphate transport protein 2A
UniProt Synonym Protein Names
Na(+)-dependent phosphate cotransporter 2A; NaPi-3; Sodium/phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; Solute carrier family 34 member 1
UniProt Synonym Gene Names
NPT2; SLC17A2; Sodium-phosphate transport protein 2A; Na(+)/Pi cotransporter 2A; NaPi-2a [Similar Products]
UniProt Entry Name
NPT2A_HUMAN
NCBI Summary for SLC34A1
This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
UniProt Comments for SLC34A1
SLC34A1: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1). Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization). Defects in SLC34A1 are the cause of Fanconi renotubular syndrome type 2 (FRTS2). It is a disease resulting from a generalized dysfunction of the proximal kidney tubule leading to decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: cell surface; brush border membrane; integral to plasma membrane; perinuclear region of cytoplasm; basolateral plasma membrane; apical plasma membrane; plasma membrane; endosome; lipid raft
Molecular Function: protein binding; protein homodimerization activity; symporter activity; protein complex binding; sodium-dependent phosphate transmembrane transporter activity; PDZ domain binding
Biological Process: indole metabolic process; response to drug; ossification; glycoprotein metabolic process; sodium ion transport; bone remodeling; response to estradiol stimulus; response to vitamin A; response to mercury ion; response to magnesium ion; response to cadmium ion; phosphate transport; response to lead ion; ion transport; phosphate ion homeostasis; positive regulation of membrane potential; kidney development; transmembrane transport; protein homooligomerization
Disease: Fanconi Renotubular Syndrome 2; Nephrolithiasis/osteoporosis, Hypophosphatemic, 1
Research Articles on SLC34A1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with SLC34A1 elisa kit
Pathways associated with SLC34A1 elisa kit
Diseases associated with SLC34A1 elisa kit
Organs/Tissues associated with SLC34A1 elisa kit
|