NP_062818.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
77,403 Da
NCBI Official Full Name
solute carrier organic anion transporter family member 1B3
NCBI Official Synonym Full Names
solute carrier organic anion transporter family, member 1B3
NCBI Official Synonym Symbols
LST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13 [Similar Products]
NCBI Protein Information
solute carrier organic anion transporter family member 1B3; organic anion transporter 8; organic anion transporter LST-3c; organic anion-transporting polypeptide 8; liver-specific organic anion transporter 2; liver-specific organic anion transporter 3TM13; solute carrier family 21 (organic anion transporter), member 8
UniProt Protein Name
Solute carrier organic anion transporter family member 1B3
UniProt Synonym Protein Names
Liver-specific organic anion transporter 2; LST-2; Organic anion transporter 8; Organic anion-transporting polypeptide 8; OATP-8; Solute carrier family 21 member 8
UniProt Synonym Gene Names
UniProt Entry Name
SO1B3_HUMAN
NCBI Summary for SLCO1B3
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
UniProt Comments for SLCO1B3
SLCO1B3: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.
Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: organic anion transmembrane transporter activity
Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport
Disease: Hyperbilirubinemia, Rotor Type
Research Articles on SLCO1B3
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Pathways associated with SLCO1B3 elisa kit
Diseases associated with SLCO1B3 elisa kit
Organs/Tissues associated with SLCO1B3 elisa kit
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