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SORD elisa kit :: Human sorbitol dehydrogenase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS700174
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $550 +1 FREE 8GB USB
96-Strip-Wells  /  $795 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,890 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,465 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

sorbitol dehydrogenase (SORD), ELISA Kit

 Also Known As   

Human sorbitol dehydrogenase, SDH ELISA Kit

 Product Synonym Names    Human sorbitol dehydrogenase; SDH ELISA Kit; SORD1; ; sorbitol dehydrogenase
 Product Gene Name   

SORD elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS700174 Testing Data    Testing Data PDF
 OMIM    182500
 3D Structure    ModBase 3D Structure for Q00796
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human SORD. No significant cross-reactivity or interference between Human SORD and analogues was observed.
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 Samples    Serum, urine
 Detection Range    0.312 mIU/ml-20 mIU/ml
 Sensitivity    0.078 mIU/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of SORD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SORD purchase    MBS700174 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sorbitol dehydrogenase (SORD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312 mIU/ml-20 mIU/ml in biological research samples containing SORD, with an estimated sensitivity of 0.078 mIU/ml. The ELISA analytical biochemical technique of the MBS700174 kit is based on SORD antibody-SORD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SORD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SORD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, urine. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for SORD elisa kit

   Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to SDH. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for SDH and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB (3,3',5,5' tetramethyl-benzidine) substrate solution is added to each well. Only those wells that contain SDH, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of SDH in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of SORD elisa kit    SORD elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS700174
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NCBI/Uniprot data below describe general gene information for SORD. It may not necessarily be applicable to this product.
 NCBI GI #    156627571
 NCBI GeneID    6652
 NCBI Accession #    NP_003095.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003104.5 [Other Products]
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 UniProt Primary Accession #    Q00796 [Other Products]
 UniProt Secondary Accession #    Q16682; Q9UMD6; B2R655; J3JZZ5 [Other Products]
 UniProt Related Accession #    Q00796 [Other Products]
 Molecular Weight    38,325 Da
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 NCBI Official Full Name    sorbitol dehydrogenase
 NCBI Official Synonym Full Names    sorbitol dehydrogenase
 NCBI Official Symbol    SORD [Similar Products]
 NCBI Official Synonym Symbols   
SORD1; HEL-S-95n
[Similar Products]
 NCBI Protein Information    sorbitol dehydrogenase; L-iditol 2-dehydrogenase; epididymis secretory sperm binding protein Li 95n
 UniProt Protein Name    Sorbitol dehydrogenase
 UniProt Synonym Protein Names   
L-iditol 2-dehydrogenase
 Protein Family    Sorbitol dehydrogenase
 UniProt Gene Name    SORD [Similar Products]
 UniProt Entry Name    DHSO_HUMAN
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 NCBI Summary for SORD    Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
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 UniProt Comments for SORD    Function: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm 1 PublicationManual assertion based on experiment in:Ref.9

Catalytic activity: L-iditol + NAD+ = L-sorbose + NADH.

Cofactor: Binds 1 zinc ion per subunit.
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 Research Articles on SORD    1. The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin and oral diabetic groups.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SORD elisa kitPathways associated with SORD elisa kit
 Reference Product  PubMed Publications
 HK1 elisa kit  >1 publications with SORD and HK1
 Products by Pathway  Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Pentose And Glucuronate Interconversions Pathway antibodies  Pentose And Glucuronate Interconversions Pathway Diagram
 Pentose And Glucuronate Interconversions Pathway antibodies  Pentose And Glucuronate Interconversions Pathway Diagram
 Polyol Pathway antibodies  Polyol Pathway Diagram
 Sorbitol Degradation I Pathway antibodies  Sorbitol Degradation I Pathway Diagram
Diseases associated with SORD elisa kitOrgans/Tissues associated with SORD elisa kit
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with SORD and Adenocarcinoma
 Brain Diseases Antibodies  >2 publications with SORD and Brain Diseases
 Liver Diseases Antibodies  >2 publications with SORD and Liver Diseases
 Mental Disorders Antibodies  >1 publications with SORD and Mental Disorders
 Hyperglycemia Antibodies  >1 publications with SORD and Hyperglycemia
 Liver Cirrhosis Antibodies  >1 publications with SORD and Liver Cirrhosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with SORD and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with SORD and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SORD and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with SORD and Bone
 Connective Tissue Antibodies  >4 publications with SORD and Connective Tissue
 Heart Antibodies  >3 publications with SORD and Heart
 Muscle Antibodies  >3 publications with SORD and Muscle
 Brain Antibodies  >3 publications with SORD and Brain
 Vascular Antibodies  >2 publications with SORD and Vascular
 Embryonic Tissue Antibodies  >2 publications with SORD and Embryonic Tissue
 Ear Antibodies  >1 publications with SORD and Ear
 Kidney Antibodies  >1 publications with SORD and Kidney
 Umbilical Cord Antibodies  >1 publications with SORD and Umbilical Cord
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