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SPTAN1 elisa kit :: Human spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS911505
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1), ELISA Kit

 Also Known As   

Human Spectrin alpha chain, brain, SPTAN1 ELISA Kit

 Product Synonym Names    Human Spectrin alpha chain; brain (SPTAN1) ELISA kit; (ALPHA) II-SPECTRIN; FLJ44613; NEAS; non-erythrocytic spectrin alpha; spectrin; alpha; non-erythrocytic 1 (alpha-fodrin)
 Product Gene Name   

SPTAN1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS911505 Testing Data    Testing Data PDF
 OMIM    gene 613477
 3D Structure    ModBase 3D Structure for Q13813
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human SPTAN1. No significant cross-reactivity or interference between Human SPTAN1 and analogues was observed.
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 Assay Type    Sandwich
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SPTAN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SPTAN1 purchase    MBS911505 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SPTAN1. The ELISA analytical biochemical technique of the MBS911505 kit is based on SPTAN1 antibody-SPTAN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SPTAN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SPTAN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SPTAN1 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for SPTAN1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SPTAN1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SPTAN1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SPTAN1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of SPTAN1 elisa kit    SPTAN1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS911505. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SPTAN1. It may not necessarily be applicable to this product.
 NCBI GI #    194595509
 NCBI GeneID    6709
 NCBI Accession #    NP_001123910.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130438.2 [Other Products]
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 UniProt Primary Accession #    Q13813 [Other Products]
 UniProt Secondary Accession #    Q13186; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0 [Other Products]
 UniProt Related Accession #    Q13813 [Other Products]
 Molecular Weight    284,539 Da
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 NCBI Official Full Name    spectrin alpha chain, non-erythrocytic 1 isoform 1
 NCBI Official Synonym Full Names    spectrin, alpha, non-erythrocytic 1
 NCBI Official Symbol    SPTAN1 [Similar Products]
 NCBI Official Synonym Symbols   
NEAS; EIEE5; SPTA2
[Similar Products]
 NCBI Protein Information    spectrin alpha chain, non-erythrocytic 1; alpha-fodrin; alpha-II spectrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit
 UniProt Protein Name    Spectrin alpha chain, non-erythrocytic 1
 UniProt Synonym Protein Names   
Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
 Protein Family    Spectrin
 UniProt Gene Name    SPTAN1 [Similar Products]
 UniProt Synonym Gene Names    NEAS; SPTA2 [Similar Products]
 UniProt Entry Name    SPTN1_HUMAN
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 NCBI Summary for SPTAN1    Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
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 UniProt Comments for SPTAN1    SPTAN1: a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: microtubule cytoskeleton; spectrin; membrane; intracellular membrane-bound organelle; fascia adherens; cytosol; Z disc; vesicle; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding; actin binding

Biological Process: axon guidance; apoptosis; actin filament capping; cell structure disassembly during apoptosis

Disease: Epileptic Encephalopathy, Early Infantile, 5
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 Research Articles on SPTAN1    1. hypomyelination of the cerebral white matter was revealed at the age of 1 year, and a de novo heterozygous mutation in the SPTAN1 gene was confirmed
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPTAN1 elisa kitPathways associated with SPTAN1 elisa kit
 Reference Product  PubMed Publications
 SPTBN1 elisa kit  >1 publications with SPTAN1 and SPTBN1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with SPTAN1 elisa kitOrgans/Tissues associated with SPTAN1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with SPTAN1 and Neoplasms
 Nervous System Diseases Antibodies  >4 publications with SPTAN1 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with SPTAN1 and Brain Diseases
 Atrophy Antibodies  >3 publications with SPTAN1 and Atrophy
 Seizures Antibodies  >3 publications with SPTAN1 and Seizures
 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 5 Antibodies  >2 publications with SPTAN1 and EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 5
 Stomach Neoplasms Antibodies  >1 publications with SPTAN1 and Stomach Neoplasms
 Eye Diseases Antibodies  >1 publications with SPTAN1 and Eye Diseases
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >1 publications with SPTAN1 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Eye Abnormalities Antibodies  >1 publications with SPTAN1 and Eye Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with SPTAN1 and Brain
 Blood Antibodies  >2 publications with SPTAN1 and Blood
 Vascular Antibodies  >1 publications with SPTAN1 and Vascular
 Nerve Antibodies  >1 publications with SPTAN1 and Nerve
 Stomach Antibodies  >1 publications with SPTAN1 and Stomach
 Eye Antibodies  >1 publications with SPTAN1 and Eye
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