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SPTB elisa kit :: Human spectrin, beta, erythrocytic ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9335867 SPTB elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
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 Product Name   

spectrin, beta, erythrocytic (SPTB), ELISA Kit

★Popular Item★
 Also Known As   

Human Spectrin beta chain, erythrocyte, SPTB ELISA Kit

 Product Synonym Names    Human Spectrin beta chain; erythrocyte (SPTB) ELISA kit; EL3; HS2; HSPTB1; SPH2; membrane cytoskeletal protein; spectrin beta; spectrin; beta; erythrocytic
 Product Gene Name   

SPTB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    182870
 3D Structure    ModBase 3D Structure for P11277
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Assay Type    Sandwich (Quantitative)
 Detection Range    3.12 ng/ml - 100 ng/ml.
 Sensitivity    1.0 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SPTB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SPTB purchase    MBS9335867 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the spectrin, beta, erythrocytic (SPTB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12 ng/ml - 100 ng/ml in biological research samples containing SPTB, with an estimated sensitivity of 1.0 ng/ml. The ELISA analytical biochemical technique of the MBS9335867 kit is based on SPTB antibody-SPTB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SPTB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SPTB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for SPTB elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPTB (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9335867. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SPTB. It may not necessarily be applicable to this product.
 NCBI GI #    67782319
 NCBI GeneID    6710
 NCBI Accession #    NP_000338.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000347.5 [Other Products]
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 UniProt Primary Accession #    P11277 [Other Products]
 UniProt Secondary Accession #    Q15510; Q15519 [Other Products]
 UniProt Related Accession #    P11277 [Other Products]
 Molecular Weight    246,468 Da
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 NCBI Official Full Name    spectrin beta chain, erythrocytic isoform b
 NCBI Official Synonym Full Names    spectrin, beta, erythrocytic
 NCBI Official Symbol    SPTB [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    spectrin beta chain, erythrocytic; beta-I spectrin; membrane cytoskeletal protein; spectrin beta chain, erythrocyte
 UniProt Protein Name    Spectrin beta chain, erythrocytic
 UniProt Synonym Protein Names   
Beta-I spectrin
 Protein Family    Spectrin
 UniProt Gene Name    SPTB [Similar Products]
 UniProt Synonym Gene Names    SPTB1 [Similar Products]
 UniProt Entry Name    SPTB1_HUMAN
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 NCBI Summary for SPTB    This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
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 UniProt Comments for SPTB    SPTB1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTB are the cause of elliptocytosis type 3 (EL3). EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTB are the cause of spherocytosis type 2 (SPH2); also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q23-q24.2

Cellular Component: spectrin; cell surface; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; protein heterodimerization activity; ankyrin binding; actin binding

Biological Process: axon guidance; plasma membrane organization and biogenesis; actin filament capping; hemopoiesis; porphyrin biosynthetic process

Disease: Spherocytosis, Type 2, Included
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 Research Articles on SPTB    1. analysis of glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPTB elisa kitPathways associated with SPTB elisa kit
 Reference Product  PubMed Publications
 SPTA1 elisa kit  >6 publications with SPTB and SPTA1
 EPB41 elisa kit  >2 publications with SPTB and EPB41
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
Diseases associated with SPTB elisa kitOrgans/Tissues associated with SPTB elisa kit
 Disease Name  Pubmed Publications
 Spherocytosis, Hereditary Antibodies  >15 publications with SPTB and Spherocytosis, Hereditary
 Anemia Antibodies  >14 publications with SPTB and Anemia
 Anemia, Hemolytic Antibodies  >13 publications with SPTB and Anemia, Hemolytic
 Elliptocytosis, Hereditary Antibodies  >6 publications with SPTB and Elliptocytosis, Hereditary
 Fetal Diseases Antibodies  >5 publications with SPTB and Fetal Diseases
 Necrosis Antibodies  >4 publications with SPTB and Necrosis
 Fetal Death Antibodies  >4 publications with SPTB and Fetal Death
 Nervous System Diseases Antibodies  >3 publications with SPTB and Nervous System Diseases
 Neoplasms Antibodies  >2 publications with SPTB and Neoplasms
 Hemolysis Antibodies  >2 publications with SPTB and Hemolysis
 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >9 publications with SPTB and Uterus
 Placenta Antibodies  >5 publications with SPTB and Placenta
 Nerve Antibodies  >2 publications with SPTB and Nerve
 Muscle Antibodies  >2 publications with SPTB and Muscle
 Embryonic Tissue Antibodies  >2 publications with SPTB and Embryonic Tissue
 Spleen Antibodies  >2 publications with SPTB and Spleen
 Brain Antibodies  >2 publications with SPTB and Brain
 Lung Antibodies  >1 publications with SPTB and Lung
 Mouth Antibodies  >1 publications with SPTB and Mouth
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