NP_000342.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,492 Da
NCBI Official Full Name
steryl-sulfatase
NCBI Official Synonym Full Names
steroid sulfatase (microsomal), isozyme S
NCBI Official Synonym Symbols
ES; ASC; XLI; ARSC; SSDD; ARSC1 [Similar Products]
NCBI Protein Information
steryl-sulfatase; arylsulfatase C; estrone sulfatase; steryl-sulfate sulfohydrolase
UniProt Protein Name
Steryl-sulfatase
UniProt Synonym Protein Names
Arylsulfatase C; ASC; Steroid sulfatase; Steryl-sulfate sulfohydrolase
UniProt Synonym Gene Names
UniProt Entry Name
STS_HUMAN
NCBI Summary for STS
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008]
UniProt Comments for STS
STS: Conversion of sulfated steroid precursors to estrogens during pregnancy. Defects in STS are the cause of ichthyosis X-linked (IXL). Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. Belongs to the sulfatase family.
Protein type: Lipid Metabolism - androgen and estrogen; Membrane protein, multi-pass; Membrane protein, integral; EC 3.1.6.2; Hydrolase
Chromosomal Location of Human Ortholog: Xp22.32
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; endoplasmic reticulum lumen; lysosome; plasma membrane; integral to membrane; endosome
Molecular Function: sulfuric ester hydrolase activity; metal ion binding; steryl-sulfatase activity
Biological Process: epidermis development; sphingolipid metabolic process; cellular protein metabolic process; glycosphingolipid metabolic process; female pregnancy; post-translational protein modification; steroid catabolic process
Disease: Ichthyosis, X-linked
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Pathways associated with STS elisa kit
Diseases associated with STS elisa kit
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