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SYVN1 elisa kit :: Human synovial apoptosis inhibitor 1, synoviolin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS939550
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

synovial apoptosis inhibitor 1, synoviolin (SYVN1), ELISA Kit

★Popular Item★
 Also Known As   

Human E3 ubiquitin-protein ligase synoviolin, SYVN1 ELISA Kit

 Product Synonym Names    Human E3 ubiquitin-protein ligase synoviolin (SYVN1) ELISA kit; HRD1; KIAA1810; MGC40372; synoviolin 1; synovial apoptosis inhibitor 1; synoviolin
 Product Gene Name   

SYVN1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS939550 Testing Data    Testing Data PDF
 OMIM    608046
 3D Structure    ModBase 3D Structure for Q86TM6
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human SYVN1. No significant cross-reactivity or interference between human SYVN1 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    9.375 pg/ml -600 pg/ml.
 Sensitivity    The minimum detectable dose of human SYVN1 is typically less than 2.34 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SYVN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SYVN1 purchase    MBS939550 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the synovial apoptosis inhibitor 1, synoviolin (SYVN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 9.375 pg/ml -600 pg/ml in biological research samples containing SYVN1, with an estimated sensitivity of The minimum detectable dose of human SYVN1 is typically less than 2.34 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS939550 kit is based on SYVN1 antibody-SYVN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SYVN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SYVN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SYVN1 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for SYVN1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SYVN1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SYVN1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SYVN1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of SYVN1 elisa kit    SYVN1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS939550. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SYVN1. It may not necessarily be applicable to this product.
 NCBI GI #    27436925
 NCBI GeneID    84447
 NCBI Accession #    NP_115807.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032431.2 [Other Products]
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 UniProt Primary Accession #    Q86TM6 [Other Products]
 UniProt Secondary Accession #    Q8N3K3; Q8N6E8; Q96JL5; Q96PK3 [Other Products]
 UniProt Related Accession #    Q86TM6 [Other Products]
 Molecular Weight    67,685 Da
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 NCBI Official Full Name    E3 ubiquitin-protein ligase synoviolin isoform a
 NCBI Official Synonym Full Names    synovial apoptosis inhibitor 1, synoviolin
 NCBI Official Symbol    SYVN1 [Similar Products]
 NCBI Official Synonym Symbols   
DER3; HRD1
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog
 UniProt Protein Name    E3 ubiquitin-protein ligase synoviolin
 UniProt Synonym Protein Names   
Synovial apoptosis inhibitor 1
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    SYVN1 [Similar Products]
 UniProt Synonym Gene Names    HRD1; KIAA1810 [Similar Products]
 UniProt Entry Name    SYVN1_HUMAN
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 NCBI Summary for SYVN1    This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]
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 UniProt Comments for SYVN1    SYVN1: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Membrane protein, integral; EC 6.3.2.19; Endoplasmic reticulum; Membrane protein, multi-pass; EC 6.3.2.-; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding

Biological Process: ER-associated protein catabolic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; in utero embryonic development; protein ubiquitination; protein amino acid N-linked glycosylation via asparagine
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 Research Articles on SYVN1    1. identified Hrd1 as a novel E3 ubiquitin ligase responsible for compromised Nrf2 response during liver cirrhosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SYVN1 elisa kitPathways associated with SYVN1 elisa kit
 Reference Product  PubMed Publications
 TP53 elisa kit  >1 publications with SYVN1 and TP53
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with SYVN1 elisa kitOrgans/Tissues associated with SYVN1 elisa kit
 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >10 publications with SYVN1 and Musculoskeletal Diseases
 Nervous System Diseases Antibodies  >8 publications with SYVN1 and Nervous System Diseases
 Mental Disorders Antibodies  >5 publications with SYVN1 and Mental Disorders
 Fibrosis Antibodies  >3 publications with SYVN1 and Fibrosis
 Movement Disorders Antibodies  >2 publications with SYVN1 and Movement Disorders
 Hyperplasia Antibodies  >2 publications with SYVN1 and Hyperplasia
 Neoplasms Antibodies  >2 publications with SYVN1 and Neoplasms
 Kidney Diseases Antibodies  >1 publications with SYVN1 and Kidney Diseases
 Vision Disorders Antibodies  >1 publications with SYVN1 and Vision Disorders
 Necrosis Antibodies  >1 publications with SYVN1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with SYVN1 and Brain
 Blood Antibodies  >3 publications with SYVN1 and Blood
 Nerve Antibodies  >3 publications with SYVN1 and Nerve
 Bone Antibodies  >2 publications with SYVN1 and Bone
 Liver Antibodies  >2 publications with SYVN1 and Liver
 Skin Antibodies  >2 publications with SYVN1 and Skin
 Connective Tissue Antibodies  >1 publications with SYVN1 and Connective Tissue
 Kidney Antibodies  >1 publications with SYVN1 and Kidney
 Pancreas Antibodies  >1 publications with SYVN1 and Pancreas
 Lung Antibodies  >1 publications with SYVN1 and Lung
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