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SNCA elisa kit :: Human synuclein, alpha (non A4 component of amyloid precursor) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS923972
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $550 +1 FREE 8GB USB
96-Strip-Wells  /  $795 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,890 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,465 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

synuclein, alpha (non A4 component of amyloid precursor) (SNCA), ELISA Kit

★Popular Item★
 Also Known As   

Human synuclein, alpha (non A4 component of amyloid precursor) oligomer, SNCA oligomer ELISA Kit

 Product Synonym Names    Human synuclein; alpha (non A4 component of amyloid precursor) oligomer (SNCA oligomer) ELISA kit; MGC110988; NACP; PARK1; PARK4; PD1; OTTHUMP00000161559; OTTHUMP00000161561; alpha-synuclein; alpha-synuclein; isoform NACP140; non A-beta component of AD amyloid; synuclein; alpha (non A4 component of amyloid precursor)
 Product Gene Name   

SNCA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS923972 Testing Data    Testing Data PDF
 OMIM    605543
 3D Structure    ModBase 3D Structure for P37840
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human SNCA. No significant cross-reactivity or interference between Human SNCA and analogues was observed.
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 Samples    Serum, plasma
 Assay Type    Sandwich
 Detection Range    0.312 ng/ml-20 ng/ml
 Sensitivity    0.078 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SNCA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SNCA purchase    MBS923972 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the synuclein, alpha (non A4 component of amyloid precursor) (SNCA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312 ng/ml-20 ng/ml in biological research samples containing SNCA, with an estimated sensitivity of 0.078 ng/ml. The ELISA analytical biochemical technique of the MBS923972 kit is based on SNCA antibody-SNCA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SNCA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SNCA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SNCA elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for SNCA oligomer has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SNCA oligomer present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SNCA oligomer is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SNCA oligomer bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of SNCA elisa kit    SNCA elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS923972. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    4507109
 NCBI GeneID    6622
 NCBI Accession #    NP_000336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000345.3 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    14,460 Da
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 NCBI Official Full Name    alpha-synuclein isoform NACP140
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for SNCA    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: Golgi apparatus; nuclear outer membrane; rough endoplasmic reticulum; mitochondrion; lysosome; fibril; extracellular region; terminal button; cell cortex; inclusion body; cytosol; mitochondrial respiratory chain complex I; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; nucleus; cell junction

Molecular Function: protein domain specific binding; identical protein binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; oxidoreductase activity; Hsp70 protein binding; calcium ion binding; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; tau protein binding; fatty acid binding; alpha-tubulin binding

Biological Process: regulation of acyl-CoA biosynthetic process; adult locomotory behavior; positive regulation of apoptosis; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of monooxygenase activity; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; regulation of macrophage activation; negative regulation of microtubule polymerization; regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

Disease: Parkinson Disease 4, Autosomal Dominant; Parkinson Disease 1, Autosomal Dominant; Dementia, Lewy Body
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 Research Articles on SNCA    1. The formation of SNCA:dopamine oligomers may alter the actions of SNCA which require membrane association.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNCA elisa kitPathways associated with SNCA elisa kit
 Reference Product  PubMed Publications
 SNCB elisa kit  >73 publications with SNCA and SNCB
 MAPT elisa kit  >50 publications with SNCA and MAPT
 SNCAIP elisa kit  >30 publications with SNCA and SNCAIP
 PARK2 elisa kit  >19 publications with SNCA and PARK2
 APP elisa kit  >16 publications with SNCA and APP
 SLC6A3 elisa kit  >12 publications with SNCA and SLC6A3
 MAPK1 elisa kit  >5 publications with SNCA and MAPK1
 TOR1A elisa kit  >4 publications with SNCA and TOR1A
 BAD elisa kit  >3 publications with SNCA and BAD
 SQSTM1 elisa kit  >3 publications with SNCA and SQSTM1
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
Diseases associated with SNCA elisa kitOrgans/Tissues associated with SNCA elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >974 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >954 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >951 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >832 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >768 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >701 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >262 publications with SNCA and Lewy Body Disease
 Atrophy Antibodies  >162 publications with SNCA and Atrophy
 Nerve Degeneration Antibodies  >154 publications with SNCA and Nerve Degeneration
 Alzheimer Disease Antibodies  >131 publications with SNCA and Alzheimer Disease
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >974 publications with SNCA and Nerve
 Brain Antibodies  >651 publications with SNCA and Brain
 Blood Antibodies  >47 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >27 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >18 publications with SNCA and Kidney
 Heart Antibodies  >7 publications with SNCA and Heart
 Eye Antibodies  >7 publications with SNCA and Eye
 Bone Antibodies  >6 publications with SNCA and Bone
 Liver Antibodies  >6 publications with SNCA and Liver
 Vascular Antibodies  >5 publications with SNCA and Vascular
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