NP_001166102.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
153,848 Da
NCBI Official Full Name
tectonin beta-propeller repeat-containing protein 2 isoform 2
NCBI Official Synonym Full Names
tectonin beta-propeller repeat containing 2
NCBI Protein Information
tectonin beta-propeller repeat-containing protein 2
UniProt Protein Name
Tectonin beta-propeller repeat-containing protein 2
UniProt Synonym Protein Names
WD repeat-containing protein KIAA0329/KIAA0297
UniProt Synonym Gene Names
UniProt Entry Name
TCPR2_HUMAN
NCBI Summary for TECPR2
The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
UniProt Comments for TECPR2
TECPR2: Belongs to the WD repeat KIAA0329 family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 14q32.31
Molecular Function: protein binding
Biological Process: autophagy
Disease: Spastic Paraplegia 49, Autosomal Recessive
Research Articles on TECPR2
Precautions
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Diseases associated with TECPR2 elisa kit
Organs/Tissues associated with TECPR2 elisa kit
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