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TERT elisa kit :: Human telomerase reverse transcriptase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS943198
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

telomerase reverse transcriptase (TERT), ELISA Kit

★Popular Item★
 Also Known As   

Human Telomerase reverse transcriptase, TERT ELISA Kit

 Product Synonym Names    Human Telomerase reverse transcriptase (TERT) ELISA kit; EST2; TCS1; TP2; TRT; hEST2; telomerase catalytic subunit; telomerase reverse transcriptase
 Product Gene Name   

TERT elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS943198 Testing Data    Testing Data PDF
 OMIM    615134
 3D Structure    ModBase 3D Structure for O14746
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human TERT. No significant cross-reactivity or interference between Human TERT and analogues was observed.
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 Samples    Serum, plasma, cell culture supernates
 Assay Type    Sandwich
 Detection Range    6.25 ng/ml-400 ng/ml
 Sensitivity    1.56 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TERT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TERT purchase    MBS943198 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the telomerase reverse transcriptase (TERT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.25 ng/ml-400 ng/ml in biological research samples containing TERT, with an estimated sensitivity of 1.56 ng/ml. The ELISA analytical biochemical technique of the MBS943198 kit is based on TERT antibody-TERT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TERT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TERT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TERT elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TERT has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TERT present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TERT is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TERT bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of TERT elisa kit    TERT elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS943198. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TERT. It may not necessarily be applicable to this product.
 NCBI GI #    301129200
 NCBI GeneID    7015
 NCBI Accession #    NP_001180305.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193376.1 [Other Products]
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 UniProt Primary Accession #    O14746 [Other Products]
 UniProt Secondary Accession #    O14783; Q2XS35; Q8N6C3; Q8NG38; Q8NG46 [Other Products]
 UniProt Related Accession #    O14746 [Other Products]
 Molecular Weight    126,997 Da
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 NCBI Official Full Name    telomerase reverse transcriptase isoform 2
 NCBI Official Synonym Full Names    telomerase reverse transcriptase
 NCBI Official Symbol    TERT [Similar Products]
 NCBI Official Synonym Symbols   
TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
[Similar Products]
 NCBI Protein Information    telomerase reverse transcriptase; telomerase catalytic subunit; telomerase-associated protein 2
 UniProt Protein Name    Telomerase reverse transcriptase
 UniProt Synonym Protein Names   
HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2
 Protein Family    Telomerase reverse transcriptase
 UniProt Gene Name    TERT [Similar Products]
 UniProt Synonym Gene Names    EST2; TCS1; TRT; TP2 [Similar Products]
 UniProt Entry Name    TERT_HUMAN
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 NCBI Summary for TERT    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TERT    TERT: telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined.

Protein type: EC 2.7.7.49; Transferase; DNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nuclear telomere cap complex; telomerase holoenzyme complex; nucleolus

Molecular Function: telomerase activity; protein binding; RNA-directed RNA polymerase activity; protein homodimerization activity; DNA binding; metal ion binding; telomeric DNA binding; RNA-directed DNA polymerase activity; telomeric template RNA reverse transcriptase activity; nucleotidyltransferase activity; tRNA binding

Biological Process: mitochondrion organization and biogenesis; DNA strand elongation; RNA-dependent DNA replication; positive regulation of nitric-oxide synthase activity; telomere maintenance via telomerase; age-dependent telomere shortening; telomere maintenance; RNA interference, production of siRNA; positive regulation of Wnt receptor signaling pathway

Disease: Pulmonary Fibrosis, Idiopathic; Aplastic Anemia; Dyskeratosis Congenita, Autosomal Dominant, 1
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 Research Articles on TERT    1. Telomere maintenance through increased expression of telomerase plays an important role in the pathogenesis especially of myxoid liposarcomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TERT elisa kitPathways associated with TERT elisa kit
 Reference Product  PubMed Publications
 SRC elisa kit  >210 publications with TERT and SRC
 TEP1 elisa kit  >25 publications with TERT and TEP1
 MTOR elisa kit  >15 publications with TERT and MTOR
 RELA elisa kit  >12 publications with TERT and RELA
 AKT1 elisa kit  >12 publications with TERT and AKT1
 NCL elisa kit  >10 publications with TERT and NCL
 TPP1 elisa kit  >9 publications with TERT and TPP1
 PRKCA elisa kit  >8 publications with TERT and PRKCA
 PINX1 elisa kit  >6 publications with TERT and PINX1
 SMG6 elisa kit  >2 publications with TERT and SMG6
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
 IL2 Signaling Events Mediated By PI3K Pathway antibodies  IL2 Signaling Events Mediated By PI3K Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
Diseases associated with TERT elisa kitOrgans/Tissues associated with TERT elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1664 publications with TERT and Neoplasms
 Drug Toxicity Antibodies  >1549 publications with TERT and Drug Toxicity
 Nervous System Diseases Antibodies  >637 publications with TERT and Nervous System Diseases
 Carcinoma Antibodies  >548 publications with TERT and Carcinoma
 Cardiovascular Diseases Antibodies  >517 publications with TERT and Cardiovascular Diseases
 Skin Diseases Antibodies  >410 publications with TERT and Skin Diseases
 Liver Diseases Antibodies  >343 publications with TERT and Liver Diseases
 Ischemia Antibodies  >337 publications with TERT and Ischemia
 Neoplasms, Experimental Antibodies  >297 publications with TERT and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >280 publications with TERT and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2302 publications with TERT and Blood
 Lung Antibodies  >564 publications with TERT and Lung
 Embryonic Tissue Antibodies  >146 publications with TERT and Embryonic Tissue
 Uterus Antibodies  >93 publications with TERT and Uterus
 Thymus Antibodies  >82 publications with TERT and Thymus
 Connective Tissue Antibodies  >71 publications with TERT and Connective Tissue
 Lymph Node Antibodies  >46 publications with TERT and Lymph Node
 Lymph Antibodies  >46 publications with TERT and Lymph
 Ascites Antibodies  >12 publications with TERT and Ascites
 Uncharacterized Tissue Antibodies  >2 publications with TERT and Uncharacterized Tissue
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