NP_001153566.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,960 Da
NCBI Official Full Name
acyl-coenzyme A thioesterase 13 isoform 2
NCBI Official Synonym Full Names
acyl-CoA thioesterase 13
NCBI Protein Information
acyl-coenzyme A thioesterase 13; hypothalamus protein HT012; thioesterase superfamily member 2
UniProt Protein Name
Acyl-coenzyme A thioesterase 13
UniProt Synonym Protein Names
Thioesterase superfamily member 2Cleaved into the following chain:Acyl-coenzyme A thioesterase 13, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
ACO13_HUMAN
NCBI Summary for THEM2
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
UniProt Comments for THEM2
THEM2: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro). Belongs to the thioesterase PaaI family.
Protein type: EC 3.1.2.-
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component: mitochondrion; spindle; cytosol; nucleus
Molecular Function: acyl-CoA hydrolase activity
Biological Process: metabolic process; protein homotetramerization
Research Articles on THEM2
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Diseases associated with THEM2 elisa kit
Organs/Tissues associated with THEM2 elisa kit
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