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TXNIP elisa kit :: Human thioredoxin interacting protein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS907170
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
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 Product Name   

thioredoxin interacting protein (TXNIP), ELISA Kit

★Popular Item★
 Also Known As   

Human Thioredoxin-interacting protein, TXNIP ELISA Kit

 Product Synonym Names    Human Thioredoxin-interacting protein (TXNIP) ELISA kit; EST01027; HHCPA78; THIF; VDUP1; thioredoxin binding protein 2; upregulated by 1; 25-dihydroxyvitamin D-3; thioredoxin interacting protein
 Product Gene Name   

TXNIP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS907170 Testing Data    Testing Data PDF
 OMIM    606599
 3D Structure    ModBase 3D Structure for Q9H3M7
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human TXNIP. No significant cross-reactivity or interference between human TXNIP and analogues was observed.
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 Samples    serum, plasma, tissue homogenates.
 Assay Type    Sandwich (Quantitative)
 Detection Range    15.6 pg/ml-1000 pg/ml.
 Sensitivity    Typically less than 3.9 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TXNIP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TXNIP purchase    MBS907170 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the thioredoxin interacting protein (TXNIP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6 pg/ml-1000 pg/ml in biological research samples containing TXNIP, with an estimated sensitivity of Typically less than 3.9 pg/ml. The ELISA analytical biochemical technique of the MBS907170 kit is based on TXNIP antibody-TXNIP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TXNIP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TXNIP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Typical Testing Data/Standard Curve (for reference only) of TXNIP elisa kit    TXNIP elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS907170. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TXNIP. It may not necessarily be applicable to this product.
 NCBI GI #    171184421
 NCBI GeneID    10628
 NCBI Accession #    NP_006463.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006472.4 [Other Products]
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 UniProt Primary Accession #    Q9H3M7 [Other Products]
 UniProt Secondary Accession #    Q16226; Q6PML0; Q9BXG9; B4E3D3 [Other Products]
 UniProt Related Accession #    Q9H3M7 [Other Products]
 Molecular Weight    43,661 Da
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 NCBI Official Full Name    thioredoxin-interacting protein
 NCBI Official Synonym Full Names    thioredoxin interacting protein
 NCBI Official Symbol    TXNIP [Similar Products]
 NCBI Official Synonym Symbols   
THIF; VDUP1; HHCPA78; EST01027
[Similar Products]
 NCBI Protein Information    thioredoxin-interacting protein; thioredoxin binding protein 2; thioredoxin-binding protein 2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3
 UniProt Protein Name    Thioredoxin-interacting protein
 UniProt Synonym Protein Names   
Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1
 Protein Family    Thioredoxin-interacting protein
 UniProt Gene Name    TXNIP [Similar Products]
 UniProt Synonym Gene Names    VDUP1 [Similar Products]
 UniProt Entry Name    TXNIP_HUMAN
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 UniProt Comments for TXNIP    TXNIP: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Belongs to the arrestin family.

Protein type: Tumor suppressor; Mitochondrial; Apoptosis; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: cytoplasm; mitochondrial intermembrane space; cytosol; nucleus

Molecular Function: enzyme inhibitor activity; protein binding; ubiquitin protein ligase binding

Biological Process: response to drug; transcription, DNA-dependent; positive regulation of apoptosis; platelet-derived growth factor receptor signaling pathway; negative regulation of cell division; negative regulation of transcription from RNA polymerase II promoter; cell cycle; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; response to hydrogen peroxide; response to mechanical stimulus; protein import into nucleus; negative regulation of catalytic activity; response to glucose stimulus; innate immune response; response to progesterone stimulus; response to calcium ion
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 Research Articles on TXNIP    1. The results for the first time demonstrate FAK-regulated TXNIP expression which is important for apoptotic, survival and oxidative stress signaling pathways in cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TXNIP elisa kitPathways associated with TXNIP elisa kit
 Reference Product  PubMed Publications
 TXN elisa kit  >8 publications with TXNIP and TXN
 ZBTB16 elisa kit  >3 publications with TXNIP and ZBTB16
 TXNRD1 elisa kit  >3 publications with TXNIP and TXNRD1
 HDAC1 elisa kit  >3 publications with TXNIP and HDAC1
 SCEL elisa kit  >1 publications with TXNIP and SCEL
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The NLRP3 Inflammasome Pathway antibodies  The NLRP3 Inflammasome Pathway Diagram
Diseases associated with TXNIP elisa kitOrgans/Tissues associated with TXNIP elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >72 publications with TXNIP and Neoplasms
 Cardiovascular Diseases Antibodies  >34 publications with TXNIP and Cardiovascular Diseases
 Inflammation Antibodies  >28 publications with TXNIP and Inflammation
 Carcinoma Antibodies  >16 publications with TXNIP and Carcinoma
 Liver Diseases Antibodies  >14 publications with TXNIP and Liver Diseases
 Necrosis Antibodies  >14 publications with TXNIP and Necrosis
 Heart Diseases Antibodies  >12 publications with TXNIP and Heart Diseases
 Drug Toxicity Antibodies  >12 publications with TXNIP and Drug Toxicity
 Adenocarcinoma Antibodies  >12 publications with TXNIP and Adenocarcinoma
 Breast Neoplasms Antibodies  >11 publications with TXNIP and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >59 publications with TXNIP and Blood
 Vascular Antibodies  >30 publications with TXNIP and Vascular
 Liver Antibodies  >29 publications with TXNIP and Liver
 Pancreas Antibodies  >25 publications with TXNIP and Pancreas
 Heart Antibodies  >24 publications with TXNIP and Heart
 Muscle Antibodies  >20 publications with TXNIP and Muscle
 Kidney Antibodies  >19 publications with TXNIP and Kidney
 Brain Antibodies  >11 publications with TXNIP and Brain
 Nerve Antibodies  >9 publications with TXNIP and Nerve
 Eye Antibodies  >9 publications with TXNIP and Eye
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