NP_001163886.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
133,958 Da
NCBI Official Full Name
tight junction protein ZO-2 isoform 4
NCBI Official Synonym Full Names
tight junction protein 2
NCBI Official Synonym Symbols
ZO2; X104; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11 [Similar Products]
NCBI Protein Information
tight junction protein ZO-2; zona occludens 2; zonula occludens protein 2; Friedreich ataxia region gene X104 (tight junction protein ZO-2)
UniProt Protein Name
Tight junction protein ZO-2
UniProt Synonym Protein Names
Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2
UniProt Synonym Gene Names
UniProt Entry Name
ZO2_HUMAN
NCBI Summary for TJP2
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for TJP2
ZO2: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues..
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q13-q21
Cellular Component: nucleoplasm; adherens junction; tight junction; cytoplasm; plasma membrane; cell junction; cytosol
Molecular Function: protein binding, bridging; protein C-terminus binding; protein domain specific binding; guanylate kinase activity; protein binding
Biological Process: response to organic substance; apoptosis; nucleotide phosphorylation; intestinal absorption; cell structure disassembly during apoptosis
Disease: Hypercholanemia, Familial; Cholestasis, Progressive Familial Intrahepatic, 4
Research Articles on TJP2
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Products associated with TJP2 elisa kit
Pathways associated with TJP2 elisa kit
Diseases associated with TJP2 elisa kit
Organs/Tissues associated with TJP2 elisa kit
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