NP_001171655.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,421 Da
NCBI Official Full Name
transcobalamin-2 isoform 2
NCBI Official Synonym Full Names
transcobalamin II
NCBI Official Synonym Symbols
II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750 [Similar Products]
NCBI Protein Information
transcobalamin-2; macrocytic anemia; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia
UniProt Protein Name
Transcobalamin-2
UniProt Synonym Protein Names
Transcobalamin II; TC II; TCII
UniProt Synonym Gene Names
UniProt Entry Name
TCO2_HUMAN
NCBI Summary for TC
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for TC
TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: extracellular space; lysosomal lumen; extracellular region; endosome
Molecular Function: metal ion binding; cobalamin binding
Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process
Disease: Transcobalamin Ii Deficiency
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Products associated with TC elisa kit
Pathways associated with TC elisa kit
Diseases associated with TC elisa kit
Organs/Tissues associated with TC elisa kit
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