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TCN2 elisa kit :: Human transcobalamin II; macrocytic anemia ELISA Kit

Scan QR to view Datasheet Catalog #    MBS919952 TCN2 elisa kit
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

transcobalamin II; macrocytic anemia (TCN2), ELISA Kit

★Popular Item★
 Also Known As   

Human Transcobalamin-2, TCN2 ELISA Kit

 Product Synonym Names    Human Transcobalamin-2 (TCN2) ELISA kit; D22S676; D22S750; TC2; transcobalamin II; transcobalamin II; macrocytic anemia
 Product Gene Name   

TCN2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    613441
 3D Structure    ModBase 3D Structure for P20062
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human TCN2. No significant cross-reactivity or interference between human TCN2 and analogues was observed.
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 Samples    serum, plasma, tissue homogenates.
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.156 ng/ml-10 ng/ml.
 Sensitivity    Typically less than 0.039 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TCN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TCN2 purchase    MBS919952 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the transcobalamin II; macrocytic anemia (TCN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156 ng/ml-10 ng/ml in biological research samples containing TCN2, with an estimated sensitivity of Typically less than 0.039 ng/ml. The ELISA analytical biochemical technique of the MBS919952 kit is based on TCN2 antibody-TCN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TCN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TCN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Sample Manual Insert of MBS919952. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TCN2. It may not necessarily be applicable to this product.
 NCBI GI #    21071010
 NCBI GeneID    6948
 NCBI Accession #    NP_000346.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000355.3 [Other Products]
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 UniProt Primary Accession #    P20062 [Other Products]
 UniProt Secondary Accession #    Q96FD4; Q9BVI8; Q9UCI5; Q9UCI6; Q9UDM0 [Other Products]
 UniProt Related Accession #    P20062; AAB25526 [Other Products]
 Molecular Weight    47,535 Da
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 NCBI Official Full Name    transcobalamin-2 isoform 1
 NCBI Official Synonym Full Names    transcobalamin II
 NCBI Official Symbol    TCN2 [Similar Products]
 NCBI Official Synonym Symbols   
II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750
[Similar Products]
 NCBI Protein Information    transcobalamin-2; macrocytic anemia; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia
 UniProt Protein Name    Transcobalamin-2
 UniProt Synonym Protein Names   
Transcobalamin II; TC II; TCII
 Protein Family    Transcobalamin
 UniProt Gene Name    TCN2 [Similar Products]
 UniProt Synonym Gene Names    TC2; TC-2; TC II; TCII [Similar Products]
 UniProt Entry Name    TCO2_HUMAN
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 NCBI Summary for TCN2    This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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 UniProt Comments for TCN2    TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: lysosomal lumen; extracellular space; extracellular region; endosome

Molecular Function: metal ion binding; cobalamin binding

Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process

Disease: Transcobalamin Ii Deficiency
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 Research Articles on TCN2    1. Report TCN2 mutations causing transcobalamin deficiency in a family.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TCN2 elisa kitDiseases associated with TCN2 elisa kit
 Products by Pathway  Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Disease Name  Pubmed Publications
 TRANSCOBALAMIN II DEFICIENCY Antibodies  >9 publications with TCN2 and TRANSCOBALAMIN II DEFICIENCY
 Cardiovascular Diseases Antibodies  >6 publications with TCN2 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >5 publications with TCN2 and Vascular Diseases
 Anemia Antibodies  >4 publications with TCN2 and Anemia
 Brain Diseases Antibodies  >4 publications with TCN2 and Brain Diseases
 Anemia, Megaloblastic Antibodies  >4 publications with TCN2 and Anemia, Megaloblastic
 Cleft Lip Antibodies  >3 publications with TCN2 and Cleft Lip
 Anemia, Macrocytic Antibodies  >3 publications with TCN2 and Anemia, Macrocytic
 Neurologic Manifestations Antibodies  >2 publications with TCN2 and Neurologic Manifestations
 Pancytopenia Antibodies  >2 publications with TCN2 and Pancytopenia
Organs/Tissues associated with TCN2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with TCN2 and Blood
 Heart Antibodies  >2 publications with TCN2 and Heart
 Kidney Antibodies  >2 publications with TCN2 and Kidney
 Brain Antibodies  >2 publications with TCN2 and Brain
 Vascular Antibodies  >1 publications with TCN2 and Vascular
 Muscle Antibodies  >1 publications with TCN2 and Muscle
 Prostate Antibodies  >1 publications with TCN2 and Prostate
 Bone Marrow Antibodies  >1 publications with TCN2 and Bone Marrow
 Intestine Antibodies  >1 publications with TCN2 and Intestine
 Pancreas Antibodies  >1 publications with TCN2 and Pancreas
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