NP_005073.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
70,973 Da
NCBI Official Full Name
E3 ubiquitin/ISG15 ligase TRIM25
NCBI Official Synonym Full Names
tripartite motif containing 25
NCBI Protein Information
E3 ubiquitin/ISG15 ligase TRIM25; RING finger protein 147; zinc finger protein-147; tripartite motif-containing 25; tripartite motif protein TRIM25; estrogen-responsive finger protein; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; zinc finger protein 147 (estrogen-responsive finger protein)
UniProt Protein Name
E3 ubiquitin/ISG15 ligase TRIM25
UniProt Synonym Protein Names
Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147
UniProt Synonym Gene Names
UniProt Entry Name
TRI25_HUMAN
NCBI Summary for TRIM25
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TRIM25
TRIM25: a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.
Protein type: Ubiquitin ligase; EC 6.3.2.n3; Transcription factor; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: nucleoplasm; cytoplasm; cytosol
Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding; transcription factor activity
Biological Process: response to vitamin D; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; negative regulation of virion penetration into host cell; response to estrogen stimulus; cytokine and chemokine mediated signaling pathway; innate immune response; protein ubiquitination; positive regulation of transcription factor activity; regulation of virion penetration into host cell; defense response to virus; negative regulation of interferon type I production; activation of NF-kappaB transcription factor
Research Articles on TRIM25
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Products associated with TRIM25 elisa kit
Pathways associated with TRIM25 elisa kit
Diseases associated with TRIM25 elisa kit
Organs/Tissues associated with TRIM25 elisa kit
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