NP_055279.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,724 Da
NCBI Official Full Name
tubulointerstitial nephritis antigen
NCBI Official Synonym Full Names
tubulointerstitial nephritis antigen
NCBI Official Synonym Symbols
NCBI Protein Information
tubulointerstitial nephritis antigen
UniProt Protein Name
Tubulointerstitial nephritis antigen
UniProt Synonym Gene Names
UniProt Entry Name
TINAG_HUMAN
NCBI Summary for TBM
This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
UniProt Comments for TBM
TINAG: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: basement membrane
Molecular Function: cysteine-type endopeptidase activity; nucleotide binding; scavenger receptor activity; polysaccharide binding
Biological Process: receptor-mediated endocytosis; immune response; proteolysis; cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with TBM elisa kit
Diseases associated with TBM elisa kit
Organs/Tissues associated with TBM elisa kit
|