NP_001276052.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,586 Da
NCBI Official Full Name
tubulin beta-4A chain isoform 1
NCBI Official Synonym Full Names
tubulin, beta 4A class IVa
NCBI Protein Information
tubulin beta-4A chain; tubulin, beta 4; tubulin, beta, 5; tubulin beta-4 chain; dystonia 4, torsion (autosomal dominant)
UniProt Protein Name
Tubulin beta-4A chain
UniProt Synonym Protein Names
Tubulin 5 beta; Tubulin beta-4 chain
UniProt Synonym Gene Names
UniProt Entry Name
TBB4A_HUMAN
NCBI Summary for TUBB4
This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]
UniProt Comments for TUBB4
TUBB4: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Belongs to the tubulin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: internode region of axon; microtubule; cell soma; cytosol; nucleus; myelin sheath; cilium
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; transmembrane transport; microtubule-based process
Disease: Dystonia 4, Torsion, Autosomal Dominant
Research Articles on TUBB4
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Pathways associated with TUBB4 elisa kit
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