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ERBB4 elisa kit :: Human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS915273 ERBB4 elisa kit
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), ELISA Kit

 Also Known As   

Human Receptor tyrosine-protein kinase erbB-4, ERBB4 ELISA Kit

 Product Synonym Names    Human Receptor tyrosine-protein kinase erbB-4 (ERBB4) ELISA kit; HER4; MGC138404; p180erbB4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; receptor tyrosine-protein kinase erbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythrob; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
 Product Gene Name   

ERBB4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 615515
 3D Structure    ModBase 3D Structure for Q15303
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human ERBB4. No significant cross-reactivity or interference between human ERBB4 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Quantitative Sandwich
 Detection Range    0.156 ng/ml -10 ng/ml
 Sensitivity    Typically less than 0.039 ng/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ERBB4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ERBB4 purchase    MBS915273 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156 ng/ml -10 ng/ml in biological research samples containing ERBB4, with an estimated sensitivity of Typically less than 0.039 ng/ml. The ELISA analytical biochemical technique of the MBS915273 kit is based on ERBB4 antibody-ERBB4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERBB4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERBB4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ERBB4 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ERBB4 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ERBB4 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ERBB4 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ERBB4 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Sample Manual Insert of MBS915273. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ERBB4. It may not necessarily be applicable to this product.
 NCBI GI #    110825958
 NCBI GeneID    2066
 NCBI Accession #    NP_001036064.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042599.1 [Other Products]
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 UniProt Primary Accession #    Q15303 [Other Products]
 UniProt Secondary Accession #    Q2M1W1; Q59EW4; B7ZLD7; B7ZLE2; B7ZLE3 [Other Products]
 UniProt Related Accession #    Q15303 [Other Products]
 Molecular Weight    146,808 Da
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 NCBI Official Full Name    receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2
 NCBI Official Synonym Full Names    v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
 NCBI Official Symbol    ERBB4 [Similar Products]
 NCBI Official Synonym Symbols   
HER4; ALS19; p180erbB4
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-4
 UniProt Synonym Protein Names   
Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4Cleaved into the following chain:ERBB4 intracellular domain; 4ICD; E4ICDAlternative name(s):s80HER4
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    ERBB4 [Similar Products]
 UniProt Synonym Gene Names    HER4; 4ICD; E4ICD [Similar Products]
 UniProt Entry Name    ERBB4_HUMAN
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 NCBI Summary for ERBB4    This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ERBB4    HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.

Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; EGFR family

Chromosomal Location of Human Ortholog: 2q33.3-q34

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; basolateral plasma membrane; plasma membrane; extracellular region; integral to membrane; nucleus; cytosol; receptor complex

Molecular Function: protein binding; protein homodimerization activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding

Biological Process: lactation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; protein amino acid autophosphorylation; signal transduction; embryonic pattern specification; olfactory bulb interneuron differentiation; regulation of cell migration; negative regulation of cell proliferation; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; cell migration; cell fate commitment; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; positive regulation of phosphoinositide 3-kinase activity; cell proliferation; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; innate immune response; positive regulation of protein amino acid phosphorylation; mitochondrial fragmentation during apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis

Disease: Amyotrophic Lateral Sclerosis 19
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 Research Articles on ERBB4    1. MiR-302b is a potential molecular marker of esophageal squamous cell carcinoma and functions as a tumor suppressor by post-transcriptionally regulating ErbB4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ERBB4 elisa kitPathways associated with ERBB4 elisa kit
 Reference Product  PubMed Publications
 ERBB2 elisa kit  >422 publications with ERBB4 and ERBB2
 ERBB3 elisa kit  >348 publications with ERBB4 and ERBB3
 EGFR elisa kit  >207 publications with ERBB4 and EGFR
 NRG1 elisa kit  >149 publications with ERBB4 and NRG1
 NRG2 elisa kit  >22 publications with ERBB4 and NRG2
 BTC elisa kit  >20 publications with ERBB4 and BTC
 NRG3 elisa kit  >17 publications with ERBB4 and NRG3
 STAT5A elisa kit  >12 publications with ERBB4 and STAT5A
 GRB2 elisa kit  >11 publications with ERBB4 and GRB2
 CD44 elisa kit  >7 publications with ERBB4 and CD44
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Downregulation Of ERBB4 Signaling Pathway antibodies  Downregulation Of ERBB4 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 GRB2 Events In ERBB2 Signaling Pathway antibodies  GRB2 Events In ERBB2 Signaling Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
Diseases associated with ERBB4 elisa kitOrgans/Tissues associated with ERBB4 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >236 publications with ERBB4 and Neoplasms
 Breast Neoplasms Antibodies  >96 publications with ERBB4 and Breast Neoplasms
 Skin Diseases Antibodies  >93 publications with ERBB4 and Skin Diseases
 Carcinoma Antibodies  >86 publications with ERBB4 and Carcinoma
 Nervous System Diseases Antibodies  >49 publications with ERBB4 and Nervous System Diseases
 Heart Diseases Antibodies  >29 publications with ERBB4 and Heart Diseases
 Neoplasms, Experimental Antibodies  >29 publications with ERBB4 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >27 publications with ERBB4 and Adenocarcinoma
 Brain Diseases Antibodies  >26 publications with ERBB4 and Brain Diseases
 Lung Neoplasms Antibodies  >23 publications with ERBB4 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >183 publications with ERBB4 and Brain
 Heart Antibodies  >78 publications with ERBB4 and Heart
 Muscle Antibodies  >68 publications with ERBB4 and Muscle
 Lung Antibodies  >53 publications with ERBB4 and Lung
 Embryonic Tissue Antibodies  >46 publications with ERBB4 and Embryonic Tissue
 Mammary Gland Antibodies  >33 publications with ERBB4 and Mammary Gland
 Kidney Antibodies  >18 publications with ERBB4 and Kidney
 Pancreas Antibodies  >12 publications with ERBB4 and Pancreas
 Uterus Antibodies  >11 publications with ERBB4 and Uterus
 Connective Tissue Antibodies  >6 publications with ERBB4 and Connective Tissue
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