NP_004860.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,302 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 4B
NCBI Official Synonym Full Names
vacuolar protein sorting 4 homolog B (S. cerevisiae)
NCBI Protein Information
vacuolar protein sorting-associated protein 4B; cell migration-inducing 1; vacuolar protein sorting 4B; suppressor of K+ transport defect 1; cell migration-inducing gene 1 protein; suppressor of K(+) transport growth defect 1
UniProt Protein Name
Vacuolar protein sorting-associated protein 4B
UniProt Synonym Protein Names
Cell migration-inducing gene 1 protein; Suppressor of K(+) transport growth defect 1; Protein SKD1
UniProt Synonym Gene Names
UniProt Entry Name
VPS4B_HUMAN
NCBI Summary for VPS4B
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]
UniProt Comments for VPS4B
VPS4B: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Belongs to the AAA ATPase family.
Protein type: EC 3.6.4.6; Vesicle
Chromosomal Location of Human Ortholog: 18q21.33
Cellular Component: spindle pole; centrosome; late endosome membrane; lysosome; early endosome; cytoplasm; late endosome; vacuolar membrane; endosome membrane; nucleus; cytosol; endosome
Molecular Function: protein C-terminus binding; protein binding; ATPase activity; ATPase activity, coupled; microtubule-severing ATPase activity; ATP binding
Biological Process: viral reproduction; cell separation during cytokinesis; endosome organization and biogenesis; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; regulation of viral reproduction; intracellular cholesterol transport; viral infectious cycle; protein depolymerization; endosome transport; response to lipid; mitotic metaphase plate congression; endosome to lysosome transport via multivesicular body sorting pathway; cytoplasmic microtubule organization and biogenesis; protein transport; potassium ion transport; nuclear organization and biogenesis; vacuole organization and biogenesis
Research Articles on VPS4B
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Products associated with VPS4B elisa kit
Pathways associated with VPS4B elisa kit
Diseases associated with VPS4B elisa kit
Organs/Tissues associated with VPS4B elisa kit
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