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PROZ elisa kit :: Human vitamin K-dependent protein Z ELISA Kit

Scan QR to view Datasheet Catalog #    MBS701077
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $550 +1 FREE 8GB USB
96-Strip-Wells  /  $795 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,890 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,465 +6 FREE 8GB USB
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 Product Name   

vitamin K-dependent protein Z (PROZ), ELISA Kit

★Popular Item★
 Also Known As   

Human vitamin K-dependent protein Z, PROZ ELISA Kit

 Product Synonym Names    Human vitamin K-dependent protein Z (PROZ) ELISA kit; PZ; protein Z; vitamin K-dependent plasma glycoprotein; vitamin K-dependent protein Z
 Product Gene Name   

PROZ elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS701077 Testing Data    Testing Data PDF
 OMIM    176895
 3D Structure    ModBase 3D Structure for P22891
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human PROZ. No significant cross-reactivity or interference between Human PROZ and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Sandwich
 Detection Range    125 ng/ml-8000 ng/ml
 Sensitivity    31.25 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Blood Coagulation
 Protein Biological Process 3    Blood coagulation
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PROZ elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PROZ purchase    MBS701077 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the vitamin K-dependent protein Z (PROZ) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 125 ng/ml-8000 ng/ml in biological research samples containing PROZ, with an estimated sensitivity of 31.25 ng/ml. The ELISA analytical biochemical technique of the MBS701077 kit is based on PROZ antibody-PROZ antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PROZ antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PROZ. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PROZ elisa kit

   For samples: For the quantitative determination of human protein Z concentrations in serum, plasma, tissue homogenates.

PRINCIPLE OF THE ASSAY This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for protein Z has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any protein Z present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for protein Z is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of protein Z bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of PROZ elisa kit    PROZ elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS701077. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PROZ. It may not necessarily be applicable to this product.
 NCBI GI #    371502106
 NCBI GeneID    8858
 NCBI Accession #    NP_001243063.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256134.1 [Other Products]
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 UniProt Primary Accession #    P22891 [Other Products]
 UniProt Secondary Accession #    Q15213; Q5JVF5; Q5JVF6; A6NMB4 [Other Products]
 UniProt Related Accession #    P22891 [Other Products]
 Molecular Weight    44,744 Da
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 NCBI Official Full Name    vitamin K-dependent protein Z isoform 1
 NCBI Official Synonym Full Names    protein Z, vitamin K-dependent plasma glycoprotein
 NCBI Official Symbol    PROZ [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    vitamin K-dependent protein Z
 UniProt Protein Name    Vitamin K-dependent protein Z
 Protein Family    Vitamin K-dependent protein
 UniProt Gene Name    PROZ [Similar Products]
 UniProt Entry Name    PROZ_HUMAN
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 NCBI Summary for PROZ    This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for PROZ    Function: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
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 Research Articles on PROZ    1. Protein Z/protein Z-dependent protease inhibitor and Fxa expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PROZ elisa kitPathways associated with PROZ elisa kit
 Reference Product  PubMed Publications
 GGCX elisa kit  >1 publications with PROZ and GGCX
 SERPINA10 elisa kit  >1 publications with PROZ and SERPINA10
 Products by Pathway  Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway antibodies  Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway Diagram
 Transport Of Gamma-carboxylated Protein Precursors From The Endoplasmic Reticulum To The Golgi Apparatus Pathway antibodies  Transport Of Gamma-carboxylated Protein Precursors From The Endoplasmic Reticulum To The Golgi Apparatus Pathway Diagram
Diseases associated with PROZ elisa kitOrgans/Tissues associated with PROZ elisa kit
 Disease Name  Pubmed Publications
 Blood Coagulation Disorders Antibodies  >2 publications with PROZ and Blood Coagulation Disorders
 Inflammation Antibodies  >1 publications with PROZ and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with PROZ and Liver
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