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KCNQ1 elisa kit :: Human voltage-gated potassium channel antibody (VGKC-ab) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS702366
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $590 +1 FREE 8GB USB
96-Strip-Wells  /  $855 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,110 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,890 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

voltage-gated potassium channel antibody (VGKC-ab) (KCNQ1), ELISA Kit

 Also Known As   

Human voltage-gated potassium channel antibody, VGKC-ab ELISA Kit

 Product Synonym Names    Human voltage-gated potassium channel antibody (VGKC-ab) ELISA Kit; voltage-gated potassium channel antibody (VGKC-ab)
 Product Gene Name   

KCNQ1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS702366 Testing Data    Testing Data PDF
 OMIM    609621
 3D Structure    ModBase 3D Structure for P51787
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 Species Reactivity    Human
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 Samples    Serum
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNQ1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNQ1 purchase    MBS702366 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the voltage-gated potassium channel antibody (VGKC-ab) (KCNQ1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNQ1. The ELISA analytical biochemical technique of the MBS702366 kit is based on KCNQ1 antibody-KCNQ1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNQ1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNQ1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for KCNQ1 elisa kit

   Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with specificity antigen . Samples are then added to the appropriate microtiter plate wells and incubated. Then add Horseradish Peroxidase (HRP)-conjugated -anti-human immunoglobin to each well and incubate. Finally, substrate solutions are added to each well. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. Calculate the valence of human anti-VGKC antibody in the samples.
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 Typical Testing Data/Standard Curve (for reference only) of KCNQ1 elisa kit    KCNQ1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS702366. Click to request current manual
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NCBI/Uniprot data below describe general gene information for KCNQ1. It may not necessarily be applicable to this product.
 NCBI GI #    2465515
 NCBI GeneID    3784
 NCBI Accession #    AAC51781.1 [Other Products]
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 UniProt Primary Accession #    P51787 [Other Products]
 UniProt Secondary Accession #    O00347; O60607; O94787; Q14D14; Q7Z6G9; Q92960; Q9UMN8; Q9UMN9 [Other Products]
 UniProt Related Accession #    P51787 [Other Products]
 Molecular Weight    61,474 Da [Similar Products]
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 NCBI Official Full Name    voltage gated potassium channel
 NCBI Official Synonym Full Names    potassium voltage-gated channel, KQT-like subfamily, member 1
 NCBI Official Symbol    KCNQ1 [Similar Products]
 NCBI Official Synonym Symbols   
LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily KQT member 1; slow delayed rectifier channel subunit; voltage-gated potassium channel subunit Kv7.1; kidney and cardiac voltage dependend K+ channel; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
 UniProt Protein Name    Potassium voltage-gated channel subfamily KQT member 1
 UniProt Synonym Protein Names   
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCNQ1 [Similar Products]
 UniProt Synonym Gene Names    KCNA8; KCNA9; KVLQT1 [Similar Products]
 UniProt Entry Name    KCNQ1_HUMAN
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 NCBI Summary for KCNQ1    This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for KCNQ1    Function: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.
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 Research Articles on KCNQ1    1. our data reveal that KvLQT1 channel blockade efficiently reduces A549 and H460 cell proliferation and migration. Moreover, KvLQT1 overexpression in AD samples suggests that it could be a potential therapeutic target in lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNQ1 elisa kitPathways associated with KCNQ1 elisa kit
 Reference Product  PubMed Publications
 KCNE1 elisa kit  >492 publications with KCNQ1 and KCNE1
 KCNH2 elisa kit  >194 publications with KCNQ1 and KCNH2
 KCNE2 elisa kit  >153 publications with KCNQ1 and KCNE2
 KCNQ2 elisa kit  >71 publications with KCNQ1 and KCNQ2
 KCNE3 elisa kit  >68 publications with KCNQ1 and KCNE3
 KCNH6 elisa kit  >58 publications with KCNQ1 and KCNH6
 AKAP9 elisa kit  >13 publications with KCNQ1 and AKAP9
 KCNA5 elisa kit  >11 publications with KCNQ1 and KCNA5
 KCNA4 elisa kit  >3 publications with KCNQ1 and KCNA4
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with KCNQ1 elisa kitOrgans/Tissues associated with KCNQ1 elisa kit
 Disease Name  Pubmed Publications
 Arrhythmias, Cardiac Antibodies  >647 publications with KCNQ1 and Arrhythmias, Cardiac
 Heart Diseases Antibodies  >631 publications with KCNQ1 and Heart Diseases
 Long QT Syndrome Antibodies  >610 publications with KCNQ1 and Long QT Syndrome
 Death, Sudden, Cardiac Antibodies  >252 publications with KCNQ1 and Death, Sudden, Cardiac
 Syncope Antibodies  >122 publications with KCNQ1 and Syncope
 Tachycardia Antibodies  >88 publications with KCNQ1 and Tachycardia
 Romano-Ward Syndrome Antibodies  >85 publications with KCNQ1 and Romano-Ward Syndrome
 Diabetes Mellitus, Type 2 Antibodies  >85 publications with KCNQ1 and Diabetes Mellitus, Type 2
 Tachycardia, Ventricular Antibodies  >84 publications with KCNQ1 and Tachycardia, Ventricular
 Jervell-Lange Nielsen Syndrome Antibodies  >74 publications with KCNQ1 and Jervell-Lange Nielsen Syndrome
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >462 publications with KCNQ1 and Heart
 Blood Antibodies  >95 publications with KCNQ1 and Blood
 Kidney Antibodies  >72 publications with KCNQ1 and Kidney
 Brain Antibodies  >44 publications with KCNQ1 and Brain
 Intestine Antibodies  >42 publications with KCNQ1 and Intestine
 Ovary Antibodies  >41 publications with KCNQ1 and Ovary
 Stomach Antibodies  >40 publications with KCNQ1 and Stomach
 Lung Antibodies  >34 publications with KCNQ1 and Lung
 Pancreas Antibodies  >29 publications with KCNQ1 and Pancreas
 Liver Antibodies  >26 publications with KCNQ1 and Liver
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