NP_057171.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,690 Da
NCBI Official Full Name
protein Wnt-16 isoform 2
NCBI Official Synonym Full Names
wingless-type MMTV integration site family, member 16
NCBI Protein Information
protein Wnt-16; wingless-type MMTV integration site family member 16b
UniProt Protein Name
Protein Wnt-16
UniProt Entry Name
WNT16_HUMAN
NCBI Summary for WNT16
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
UniProt Comments for WNT16
WNT16: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: proteinaceous extracellular matrix; extracellular space; cytoplasm; extracellular region
Molecular Function: frizzled binding
Biological Process: neuron differentiation; positive regulation of phosphoinositide 3-kinase cascade; keratinocyte differentiation; Wnt receptor signaling pathway; cell fate commitment; positive regulation of JNK cascade; keratinocyte proliferation; bone remodeling
Research Articles on WNT16
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Products associated with WNT16 elisa kit
Pathways associated with WNT16 elisa kit
Diseases associated with WNT16 elisa kit
Organs/Tissues associated with WNT16 elisa kit
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