NP_071449.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,569 Da
NCBI Official Full Name
xylosyltransferase 1
NCBI Official Synonym Full Names
xylosyltransferase I
NCBI Official Synonym Symbols
XT1; XTI; XT-I; DBQD2; XYLTI; PXYLT1 [Similar Products]
NCBI Protein Information
xylosyltransferase 1; xylT-I; O-xylosyltransferase 1; xylosyltransferase iota; beta-D-xylosyltransferase 1; peptide O-xylosyltransferase 1
UniProt Protein Name
Xylosyltransferase 1
UniProt Synonym Protein Names
Peptide O-xylosyltransferase 1; Xylosyltransferase I; XT-I; XylT-I
UniProt Synonym Gene Names
UniProt Entry Name
XYLT1_HUMAN
NCBI Summary for XYLT1
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]
UniProt Comments for XYLT1
XYLT1: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Belongs to the glycosyltransferase 14 family. XylT subfamily.
Protein type: EC 2.4.2.26; Glycan Metabolism - heparan sulfate biosynthesis; Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p12.3
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; extracellular region; integral to membrane
Molecular Function: acetylglucosaminyltransferase activity; protein xylosyltransferase activity
Biological Process: glycosaminoglycan biosynthetic process; chondroitin sulfate biosynthetic process; heparan sulfate proteoglycan biosynthetic process
Disease: Desbuquois Dysplasia 2; Pseudoxanthoma Elasticum
Research Articles on XYLT1
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Pathways associated with XYLT1 elisa kit
Diseases associated with XYLT1 elisa kit
Organs/Tissues associated with XYLT1 elisa kit
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