NP_115644.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,783 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase ZNRF1
NCBI Official Synonym Full Names
zinc and ring finger 1, E3 ubiquitin protein ligase
NCBI Official Synonym Symbols
NCBI Protein Information
E3 ubiquitin-protein ligase ZNRF1; nerve injury gene 283; zinc/RING finger protein 1; zinc and ring finger protein 1; nerve injury-induced gene 283 protein
UniProt Protein Name
E3 ubiquitin-protein ligase ZNRF1
UniProt Synonym Protein Names
Nerve injury-induced gene 283 protein; Zinc/RING finger protein 1
UniProt Synonym Gene Names
UniProt Entry Name
ZNRF1_HUMAN
NCBI Summary for ZNRF1
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
UniProt Comments for ZNRF1
ZNRF1: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: synaptic vesicle membrane; membrane; lysosome; cytosol; cell junction; endosome
Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process
Research Articles on ZNRF1
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Diseases associated with ZNRF1 elisa kit
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