NP_067009.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,400 Da
NCBI Official Full Name
zona pellucida sperm-binding protein 4 preproprotein
NCBI Official Synonym Full Names
zona pellucida glycoprotein 4
NCBI Protein Information
zona pellucida sperm-binding protein 4; zona pellucida B protein; zona pellucida protein B
UniProt Protein Name
Zona pellucida sperm-binding protein 4
UniProt Synonym Protein Names
Zona pellucida glycoprotein 4; Zp-4; Zona pellucida protein BCleaved into the following chain:Processed zona pellucida sperm-binding protein 4
UniProt Synonym Gene Names
UniProt Entry Name
ZP4_HUMAN
NCBI Summary for ZP4
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]
UniProt Comments for ZP4
ZP4: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. Belongs to the ZP domain family. ZPB subfamily.
Protein type: Extracellular matrix; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: proteinaceous extracellular matrix; extracellular region; integral to membrane; plasma membrane
Molecular Function: acrosin binding; signal transducer activity
Biological Process: binding of sperm to zona pellucida; positive regulation of humoral immune response; single fertilization; positive regulation of protein kinase activity; positive regulation of T cell proliferation; multicellular organism reproduction
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Products associated with ZP4 elisa kit
Organs/Tissues associated with ZP4 elisa kit
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