NP_034906.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
25,957 Da
NCBI Official Full Name
mannose-binding protein C
NCBI Official Synonym Full Names
mannose-binding lectin (protein C) 2
NCBI Protein Information
mannose-binding protein C; RARF/P28A; mannan-binding protein; mannose binding lectin (C); RA-reactive factor P28A subunit; mannose binding lectin, liver (C)
UniProt Protein Name
Mannose-binding protein C
UniProt Synonym Protein Names
Mannan-binding protein; RA-reactive factor P28A subunit; RARF/P28A
UniProt Synonym Gene Names
UniProt Entry Name
MBL2_MOUSE
UniProt Comments for MBL-C
MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular space; collagen; extracellular region
Molecular Function: mannose binding; protease binding; protein self-association; galactose binding; calcium ion binding; carbohydrate binding; calcium-dependent protein binding; receptor binding
Biological Process: defense response to Gram-positive bacterium; immune system process; killing by host of symbiont cells; positive regulation of phagocytosis; innate immune response; complement activation, lectin pathway; negative regulation of viral reproduction; complement activation, classical pathway
Product References and Citations for MBL-C elisa kit
1. Vries de, B et al; The mannose-binding lectin pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. Am J Pathol 2004, 165: 1677 2. Trouw, L et al; Activation of the lectin pathway in murine lupus nephritis. Mol Immunol 2005, 42: 731
Research Articles on MBL-C
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Products associated with MBL-C elisa kit
Pathways associated with MBL-C elisa kit
Diseases associated with MBL-C elisa kit
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