NP_002795.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,204 Da
NCBI Official Full Name
26S protease regulatory subunit 6A
NCBI Official Synonym Full Names
proteasome 26S subunit, ATPase 3
NCBI Official Synonym Symbols
NCBI Protein Information
26S protease regulatory subunit 6A
UniProt Protein Name
26S protease regulatory subunit 6A
UniProt Synonym Protein Names
26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; Tat-binding protein 1; TBP-1
UniProt Synonym Gene Names
UniProt Entry Name
PRS6A_HUMAN
NCBI Summary for PSMC3
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
UniProt Comments for PSMC3
RPT5: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, suppresses Tat-mediated transactivation. Belongs to the AAA ATPase family.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Proteasome complex
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: cytosol; membrane; nucleoplasm; nucleus; proteasome complex
Molecular Function: ATPase activity; protein binding; TATA-binding protein binding; transcription coactivator activity; transcription corepressor activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; ER-associated protein catabolic process; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of transcriptional preinitiation complex assembly; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on PSMC3
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Pathways associated with PSMC3 elisa kit
Diseases associated with PSMC3 elisa kit
Organs/Tissues associated with PSMC3 elisa kit
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