NP_001191382.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,634 Da
NCBI Official Full Name
26S protease regulatory subunit 7 isoform 2
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, ATPase, 2
NCBI Protein Information
26S protease regulatory subunit 7; protease 26S subunit 7; proteasome 26S subunit ATPase 2; proteasome 26S subunit, ATPase, 2; putative protein product of Nbla10058; 26S proteasome AAA-ATPase subunit RPT1; mammalian suppressor of sgv-1 of yeast
UniProt Protein Name
26S protease regulatory subunit 7
UniProt Synonym Protein Names
26S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2; Protein MSS1
UniProt Synonym Gene Names
UniProt Entry Name
PRS7_HUMAN
NCBI Summary for PSMC2
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
UniProt Comments for PSMC2
RPT1: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation. Belongs to the AAA ATPase family.
Protein type: Proteasome complex; Protease
Chromosomal Location of Human Ortholog: 7q22.1-q22.3
Cellular Component: proteasome complex; nucleoplasm; membrane; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; ATPase activity; ATP binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; osteoblast differentiation; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Research Articles on PSMC2
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Products associated with PSMC2 elisa kit
Pathways associated with PSMC2 elisa kit
Diseases associated with PSMC2 elisa kit
Organs/Tissues associated with PSMC2 elisa kit
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