NP_002798.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,258 Da
NCBI Official Full Name
26S proteasome non-ATPase regulatory subunit 1 isoform 1
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 1; 26S proteasome subunit p112; 26S proteasome regulatory subunit S1; 26S proteasome regulatory subunit RPN2
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 1
UniProt Synonym Protein Names
26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112
UniProt Entry Name
PSMD1_HUMAN
NCBI Summary for PSMD1
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]
UniProt Comments for PSMD1
PSMD1: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Interacts with ADRM1. Belongs to the proteasome subunit S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: nucleoplasm; proteasome complex; membrane; proteasome regulatory particle; cytosol
Molecular Function: enzyme regulator activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on PSMD1
Precautions
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Pathways associated with PSMD1 elisa kit
Diseases associated with PSMD1 elisa kit
Organs/Tissues associated with PSMD1 elisa kit
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