NP_001257411.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,535 Da
NCBI Official Full Name
26S proteasome non-ATPase regulatory subunit 11
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit p44.5
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 11
UniProt Synonym Protein Names
26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5
UniProt Entry Name
PSD11_HUMAN
NCBI Summary for PSMD11
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for PSMD11
PSMD11: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Belongs to the proteasome subunit S9 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Proteasome complex; Protease
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleoplasm; proteasome complex; membrane; proteasome regulatory particle; nucleus; cytosol
Molecular Function: protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; stem cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; proteasome assembly; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Research Articles on PSMD11
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Products associated with PSMD11 elisa kit
Pathways associated with PSMD11 elisa kit
Diseases associated with PSMD11 elisa kit
Organs/Tissues associated with PSMD11 elisa kit
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