NP_002940.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,348 Da
NCBI Official Full Name
39S ribosomal protein L12, mitochondrial
NCBI Official Synonym Full Names
mitochondrial ribosomal protein L12
NCBI Official Synonym Symbols
5c5-2; L12mt; MRPL7; RPML12; MRPL7/L12; MRP-L31/34 [Similar Products]
NCBI Protein Information
39S ribosomal protein L12, mitochondrial; MRP-L12
UniProt Protein Name
39S ribosomal protein L12, mitochondrial
UniProt Synonym Protein Names
5c5-2
UniProt Synonym Gene Names
UniProt Entry Name
RM12_HUMAN
NCBI Summary for MRPL12
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
UniProt Comments for MRPL12
MRPL12: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
Protein type: Mitochondrial; Ribosomal
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial large ribosomal subunit
Molecular Function: protein binding; structural constituent of ribosome; RNA binding
Biological Process: mitochondrial translation; organelle organization and biogenesis; positive regulation of transcription, DNA-dependent; transcription from mitochondrial promoter
Research Articles on MRPL12
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Products associated with MRPL12 elisa kit
Pathways associated with MRPL12 elisa kit
Diseases associated with MRPL12 elisa kit
Organs/Tissues associated with MRPL12 elisa kit
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