NP_001159934.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,854 Da
NCBI Official Full Name
55 kDa erythrocyte membrane protein isoform 4
NCBI Official Synonym Full Names
membrane protein, palmitoylated 1, 55kDa
NCBI Official Synonym Symbols
MRG1; PEMP; AAG12; EMP55; DXS552E [Similar Products]
NCBI Protein Information
55 kDa erythrocyte membrane protein; p55; aging-associated gene 12; migration-related gene 1; erythrocyte membrane protein p55; palmitoylated erythrocyte membrane protein
UniProt Protein Name
55 kDa erythrocyte membrane protein
UniProt Synonym Protein Names
Membrane protein, palmitoylated 1
UniProt Synonym Gene Names
UniProt Entry Name
EM55_HUMAN
NCBI Summary for MPP1
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for MPP1
EM55: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity. Belongs to the MAGUK family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, other
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cortical cytoskeleton; stereocilium; membrane; integral to plasma membrane; intracellular
Molecular Function: guanylate kinase activity; protein binding
Biological Process: signal transduction; nucleotide phosphorylation
Research Articles on MPP1
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Diseases associated with MPP1 elisa kit
Organs/Tissues associated with MPP1 elisa kit
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