AAI12104.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,406 Da
NCBI Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
NCBI Official Synonym Full Names
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
NCBI Protein Information
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; PFK/FBPase 2; PFKFB, cardiac; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; fructose-2,6-bisphosphatase, cardiac isozyme
UniProt Protein Name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
UniProt Synonym Protein Names
6PF-2-K/Fru-2,6-P2ase heart-type isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105); Fructose-2,6-bisphosphatase (EC:3.1.3.46)
UniProt Synonym Gene Names
UniProt Entry Name
F262_HUMAN
NCBI Summary for PFKFB2
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PFKFB2
PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described.
Protein type: Phosphatase (non-protein); Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; Kinase, other; EC 3.1.3.46; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytosol
Molecular Function: protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; protein kinase binding; ATP binding
Biological Process: glycolysis; positive regulation of insulin secretion; glucose metabolic process; pathogenesis; fructose 2,6-bisphosphate metabolic process; glucose catabolic process; dephosphorylation; lactate metabolic process; carbohydrate phosphorylation; carbohydrate metabolic process; response to glucose stimulus; positive regulation of glucokinase activity; fructose metabolic process
Research Articles on PFKFB2
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Pathways associated with PFKFB2 elisa kit
Diseases associated with PFKFB2 elisa kit
Organs/Tissues associated with PFKFB2 elisa kit
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