NP_008968.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,460 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 8
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 8
UniProt Synonym Protein Names
METH-2; METH-8
UniProt Synonym Gene Names
UniProt Entry Name
ATS8_HUMAN
NCBI Summary for ADAMTS8
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS8
ADAMTS8: Has anti-angiogenic properties.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Cell cycle regulation; EC 3.4.24.-; Protease; Secreted
Chromosomal Location of Human Ortholog: 11q25
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: heparin binding; integrin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; low affinity phosphate transmembrane transporter activity
Biological Process: negative regulation of cell proliferation; proteolysis
Research Articles on ADAMTS8
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Pathways associated with ADAMTS8 elisa kit
Diseases associated with ADAMTS8 elisa kit
Organs/Tissues associated with ADAMTS8 elisa kit
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