Q99996.3
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
455,423 Da
NCBI Official Full Name
A-kinase anchor protein 9
NCBI Official Synonym Full Names
A kinase (PRKA) anchor protein 9
NCBI Official Synonym Symbols
LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16A [Similar Products]
NCBI Protein Information
A-kinase anchor protein 9; protein yotiao; protein hyperion; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein kinase A anchoring protein 9; A kinase (PRKA) anchor protein (yotiao) 9; protein phosphatase 1, regulatory subunit 45; centrosome- and Golgi-localized PKN-associated protein; centrosome- and golgi-localized protein kinase N-associated protein
UniProt Protein Name
A-kinase anchor protein 9
UniProt Synonym Protein Names
A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein; CG-NAP; Protein hyperion; Protein kinase A-anchoring protein 9; PRKA9; Protein yotiao
UniProt Synonym Gene Names
AKAP350; AKAP450; KIAA0803; AKAP-9; AKAP 350; hgAKAP 350; AKAP 450; CG-NAP; PRKA9 [Similar Products]
UniProt Entry Name
AKAP9_HUMAN
NCBI Summary for AKAP9
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]
UniProt Comments for AKAP9
AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: Golgi apparatus; centrosome; pericentriolar material; voltage-gated potassium channel complex; cytoskeleton; intracellular membrane-bound organelle; cytosol
Molecular Function: protein binding; potassium channel regulator activity; protein complex scaffold; receptor binding
Biological Process: synaptic transmission; transport; organelle organization and biogenesis; spermatogenesis; mitotic cell cycle; signal transduction; G2/M transition of mitotic cell cycle; positive regulation of peptidyl-serine phosphorylation; Sertoli cell development
Disease: Long Qt Syndrome 11
Research Articles on AKAP9
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Pathways associated with AKAP9 elisa kit
Diseases associated with AKAP9 elisa kit
Organs/Tissues associated with AKAP9 elisa kit
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