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ACACA elisa kit :: Monkey Acetyl Coenzyme A Carboxylase Alpha ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008498 ACACA elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acetyl Coenzyme A Carboxylase Alpha (ACACA), ELISA Kit

 Also Known As   

Monkey Acetyl Coenzyme A Carboxylase Alpha ELISA Kit

 Product Gene Name   

ACACA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    200350
 3D Structure    ModBase 3D Structure for Q13085
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACACA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACACA purchase    MBS008498 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Acetyl Coenzyme A Carboxylase Alpha (ACACA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACACA. The ELISA analytical biochemical technique of the MBS008498 kit is based on ACACA antibody-ACACA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACACA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACACA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.
 NCBI GI #    38679960
 NCBI GeneID    31
 NCBI Accession #    NP_942131.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_198834.2 [Other Products]
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 UniProt Primary Accession #    Q13085 [Other Products]
 UniProt Secondary Accession #    Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3; B2RP68 [Other Products]
 UniProt Related Accession #    Q13085 [Other Products]
 Molecular Weight    265,554 Da
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 NCBI Official Full Name    acetyl-CoA carboxylase 1 isoform 1
 NCBI Official Synonym Full Names    acetyl-CoA carboxylase alpha
 NCBI Official Symbol    ACACA [Similar Products]
 NCBI Official Synonym Symbols   
ACC; ACAC; ACC1; ACCA; ACACAD
[Similar Products]
 NCBI Protein Information    acetyl-CoA carboxylase 1; ACC-alpha; acetyl-Coenzyme A carboxylase alpha
 UniProt Protein Name    Acetyl-CoA carboxylase 1
 UniProt Synonym Protein Names   
ACC-alpha
 UniProt Gene Name    ACACA [Similar Products]
 UniProt Synonym Gene Names    ACAC; ACC1; ACCA; ACC1 [Similar Products]
 UniProt Entry Name    ACACA_HUMAN
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 NCBI Summary for ACACA    Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACACA    ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Lipid Metabolism - fatty acid biosynthesis; EC 6.3.4.14; EC 6.4.1.2; Carbohydrate Metabolism - propanoate; Ligase; Carbohydrate Metabolism - pyruvate

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton

Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding

Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; positive regulation of cellular metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; cellular lipid metabolic process; carnitine shuttle; biotin metabolic process; protein homotetramerization; multicellular organismal protein metabolic process; energy reserve metabolic process; tissue homeostasis; water-soluble vitamin metabolic process; fatty acid biosynthetic process

Disease: Acetyl-coa Carboxylase Deficiency
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 Research Articles on ACACA    1. Single nucleotide polymorphisms in the ACACA and ACLY genes are associated with a relative change in plasma triglycierides following fish oil supplementation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACACA elisa kitDiseases associated with ACACA elisa kit
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Biotin Transport And Metabolism Pathway antibodies  Biotin Transport And Metabolism Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >25 publications with ACACA and Fatty Liver
 Neoplasms Antibodies  >8 publications with ACACA and Neoplasms
 Inflammation Antibodies  >8 publications with ACACA and Inflammation
 Insulin Resistance Antibodies  >7 publications with ACACA and Insulin Resistance
 Liver Diseases Antibodies  >6 publications with ACACA and Liver Diseases
 Weight Loss Antibodies  >4 publications with ACACA and Weight Loss
 Weight Gain Antibodies  >3 publications with ACACA and Weight Gain
 Hypertriglyceridemia Antibodies  >3 publications with ACACA and Hypertriglyceridemia
 Necrosis Antibodies  >3 publications with ACACA and Necrosis
 Atherosclerosis Antibodies  >2 publications with ACACA and Atherosclerosis
Organs/Tissues associated with ACACA elisa kit
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >37 publications with ACACA and Adipose Tissue
 Liver Antibodies  >29 publications with ACACA and Liver
 Muscle Antibodies  >19 publications with ACACA and Muscle
 Connective Tissue Antibodies  >18 publications with ACACA and Connective Tissue
 Mammary Gland Antibodies  >17 publications with ACACA and Mammary Gland
 Blood Antibodies  >16 publications with ACACA and Blood
 Vascular Antibodies  >5 publications with ACACA and Vascular
 Brain Antibodies  >4 publications with ACACA and Brain
 Ovary Antibodies  >3 publications with ACACA and Ovary
 Thyroid Antibodies  >3 publications with ACACA and Thyroid
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