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ATF6 elisa kit :: Monkey Activating Transcription Factor 6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS031662 ATF6 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activating Transcription Factor 6 (ATF6), ELISA Kit

 Also Known As   

Monkey Activating Transcription Factor 6 ELISA Kit

 Product Gene Name   

ATF6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (161736034..161933860). Location: 1q22-q23
 OMIM    605537
 3D Structure    ModBase 3D Structure for P18850
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ATF6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATF6 purchase    MBS031662 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activating Transcription Factor 6 (ATF6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATF6. The ELISA analytical biochemical technique of the MBS031662 kit is based on ATF6 antibody-ATF6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATF6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATF6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ATF6. It may not necessarily be applicable to this product.
 NCBI GI #    2245630
 NCBI GeneID    22926
 NCBI Accession #    AAB64434.1 [Other Products]
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 UniProt Primary Accession #    P18850 [Other Products]
 UniProt Secondary Accession #    O15139; Q5VW62; Q6IPB5; Q9UEC9 [Other Products]
 UniProt Related Accession #    P18850 [Other Products]
 Molecular Weight    74,585 Da
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 NCBI Official Full Name    ATF6
 NCBI Official Synonym Full Names    activating transcription factor 6
 NCBI Official Symbol    ATF6 [Similar Products]
 NCBI Official Synonym Symbols   
ATF6A
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-6 alpha
 UniProt Synonym Protein Names   
Activating transcription factor 6 alpha
 Protein Family    Cyclic AMP-dependent transcription factor
 UniProt Gene Name    ATF6 [Similar Products]
 UniProt Synonym Gene Names    cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha [Similar Products]
 UniProt Entry Name    ATF6A_HUMAN
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 NCBI Summary for ATF6    This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
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 UniProt Comments for ATF6    ATF6A: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. Belongs to the bZIP family. ATF subfamily.

Protein type: Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane; nuclear envelope; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; transcription, DNA-dependent; protein folding; unfolded protein response; positive regulation of transcription of target genes involved in unfolded protein response; response to stress; signal transduction

Disease: Achromatopsia 7
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 Research Articles on ATF6    1. results demonstrate that ER stress-related proteins, particularly ATF6 and its downstream molecule CHOP, are involved in ox-LDL-induced cholesterol accumulation and apoptosis in macrophages
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATF6 elisa kitPathways associated with ATF6 elisa kit
 Reference Product  PubMed Publications
 DDIT3 elisa kit  >143 publications with ATF6 and DDIT3
 HSPA5 elisa kit  >24 publications with ATF6 and HSPA5
 YY1 elisa kit  >7 publications with ATF6 and YY1
 CALR elisa kit  >3 publications with ATF6 and CALR
 SREBF2 elisa kit  >3 publications with ATF6 and SREBF2
 MBTPS2 elisa kit  >3 publications with ATF6 and MBTPS2
 MBTPS1 elisa kit  >2 publications with ATF6 and MBTPS1
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By ATF6-alpha Pathway antibodies  Activation Of Chaperone Genes By ATF6-alpha Pathway Diagram
 Activation Of Chaperones By ATF6-alpha Pathway antibodies  Activation Of Chaperones By ATF6-alpha Pathway Diagram
 Activation Of Genes By ATF4 Pathway antibodies  Activation Of Genes By ATF4 Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulated Gene Expression Pathway antibodies  PERK Regulated Gene Expression Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with ATF6 elisa kitOrgans/Tissues associated with ATF6 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >74 publications with ATF6 and Neoplasms
 Neurodegenerative Diseases Antibodies  >38 publications with ATF6 and Neurodegenerative Diseases
 Brain Diseases Antibodies  >36 publications with ATF6 and Brain Diseases
 Liver Diseases Antibodies  >33 publications with ATF6 and Liver Diseases
 Inflammation Antibodies  >32 publications with ATF6 and Inflammation
 Drug Toxicity Antibodies  >30 publications with ATF6 and Drug Toxicity
 Heart Diseases Antibodies  >19 publications with ATF6 and Heart Diseases
 Necrosis Antibodies  >18 publications with ATF6 and Necrosis
 Insulin Resistance Antibodies  >14 publications with ATF6 and Insulin Resistance
 Lung Diseases Antibodies  >14 publications with ATF6 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >17 publications with ATF6 and Eye
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