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AICDA elisa kit :: Monkey Activation-induced cytidine deaminase (AICDA) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7229120 AICDA elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activation-induced cytidine deaminase (AICDA), ELISA Kit

 Also Known As   

Monkey Activation-induced cytidine deaminase (AICDA) ELISA Kit

 Product Gene Name   

AICDA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 605258
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 Species Reactivity    Monkey
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AICDA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AICDA purchase    MBS7229120 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activation-induced cytidine deaminase (AICDA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AICDA. The ELISA analytical biochemical technique of the MBS7229120 kit is based on AICDA antibody-AICDA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AICDA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AICDA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for AICDA elisa kit    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
 NCBI GI #    9988410
 NCBI GeneID    57379
 NCBI Accession #    BAB12721.1 [Other Products]
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 UniProt Secondary Accession #    Q6QJ81; Q8NFC1 [Other Products]
 UniProt Related Accession #    Q9GZX7 [Other Products]
 Molecular Weight    22,614 Da
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 NCBI Official Full Name    activation-induced cytidine deaminase
 NCBI Official Synonym Full Names    activation-induced cytidine deaminase
 NCBI Official Symbol    AICDA [Similar Products]
 NCBI Official Synonym Symbols   
AID; ARP2; CDA2; HIGM2; HEL-S-284
[Similar Products]
 NCBI Protein Information    single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos
 UniProt Protein Name    Single-stranded DNA cytosine deaminase
 UniProt Synonym Protein Names   
Activation-induced cytidine deaminase; Cytidine aminohydrolase
 Protein Family    Single-stranded DNA cytosine deaminase
 UniProt Gene Name    AICDA [Similar Products]
 UniProt Synonym Gene Names    AID [Similar Products]
 UniProt Entry Name    AICDA_HUMAN
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 NCBI Summary for AICDA    This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
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 UniProt Comments for AICDA    AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Hydrolase; EC 3.5.4.38

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity

Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing

Disease: Immunodeficiency With Hyper-igm, Type 2
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 Research Articles on AICDA    1. AID lacking the C terminus is impaired in its ability to recruit nonhomologous end joining repair factors, resulting in accumulation of double-strand breaks that undergo aberrant resection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AICDA elisa kitPathways associated with AICDA elisa kit
 Reference Product  PubMed Publications
 TNFSF13B elisa kit  >6 publications with AICDA and TNFSF13B
 STAT6 elisa kit  >5 publications with AICDA and STAT6
 IL4 elisa kit  >3 publications with AICDA and IL4
 Products by Pathway  Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Salvage Pathways Of Pyrimidine Deoxyribonucleotides antibodies  Salvage Pathways Of Pyrimidine Deoxyribonucleotides Diagram
 Salvage Pathways Of Pyrimidine Ribonucleotides antibodies  Salvage Pathways Of Pyrimidine Ribonucleotides Diagram
Diseases associated with AICDA elisa kitOrgans/Tissues associated with AICDA elisa kit
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >61 publications with AICDA and Leukemia
 Leukemia, Lymphoid Antibodies  >43 publications with AICDA and Leukemia, Lymphoid
 Inflammation Antibodies  >36 publications with AICDA and Inflammation
 Autoimmune Diseases Antibodies  >36 publications with AICDA and Autoimmune Diseases
 Necrosis Antibodies  >27 publications with AICDA and Necrosis
 Disease Models, Animal Antibodies  >24 publications with AICDA and Disease Models, Animal
 Hyper-IgM Immunodeficiency Syndrome Antibodies  >19 publications with AICDA and Hyper-IgM Immunodeficiency Syndrome
 Nervous System Diseases Antibodies  >12 publications with AICDA and Nervous System Diseases
 Adenocarcinoma Antibodies  >12 publications with AICDA and Adenocarcinoma
 Leukemia, Myeloid Antibodies  >10 publications with AICDA and Leukemia, Myeloid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >442 publications with AICDA and Blood
 Lymph Node Antibodies  >96 publications with AICDA and Lymph Node
 Lymph Antibodies  >25 publications with AICDA and Lymph
 Kidney Antibodies  >25 publications with AICDA and Kidney
 Tonsil Antibodies  >11 publications with AICDA and Tonsil
 Pharynx Antibodies  >7 publications with AICDA and Pharynx
 Testis Antibodies  >2 publications with AICDA and Testis
 Pancreas Antibodies  >1 publications with AICDA and Pancreas
 Uncharacterized Tissue Antibodies  >1 publications with AICDA and Uncharacterized Tissue
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