NP_058431.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,906 Da
NCBI Official Full Name
adapter molecule crk isoform a
NCBI Official Synonym Full Names
v-crk avian sarcoma virus CT10 oncogene homolog
NCBI Official Synonym Symbols
NCBI Protein Information
adapter molecule crk; proto-oncogene c-Crk
UniProt Protein Name
Adapter molecule crk
UniProt Synonym Protein Names
Proto-oncogene c-Crk; p38
UniProt Entry Name
CRK_HUMAN
NCBI Summary for CRK
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for CRK
CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Oncoprotein
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol; actin cytoskeleton
Molecular Function: protein phosphorylated amino acid binding; protein binding; SH3/SH2 adaptor activity; ephrin receptor binding; SH2 domain binding
Biological Process: regulation of transcription from RNA polymerase II promoter; platelet activation; regulation of Rac protein signal transduction; nerve growth factor receptor signaling pathway; activation of MAPKK activity; regulation of actin cytoskeleton organization and biogenesis; insulin receptor signaling pathway; ephrin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation
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Products associated with CRK elisa kit
Pathways associated with CRK elisa kit
Diseases associated with CRK elisa kit
Organs/Tissues associated with CRK elisa kit
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