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AGC elisa kit :: Monkey Aggrecan ELISA Kit

Scan QR to view Datasheet Catalog #    MBS022493 AGC elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Aggrecan (AGC), ELISA Kit

 Also Known As   

Monkey Aggrecan ELISA Kit

 Product Gene Name   

AGC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 15; NC_000015.9 (89346674..89418585). Location: 15q26.1
 OMIM    155760
 3D Structure    ModBase 3D Structure for P16112
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of AGC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AGC purchase    MBS022493 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Aggrecan (AGC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AGC. The ELISA analytical biochemical technique of the MBS022493 kit is based on AGC antibody-AGC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AGC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AGC. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for AGC. It may not necessarily be applicable to this product.
 NCBI GI #    22209083
 NCBI GeneID    176
 NCBI Accession #    AAH36445.1 [Other Products]
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 UniProt Primary Accession #    P16112 [Other Products]
 UniProt Secondary Accession #    Q13650; Q9UCD3; Q9UCP4; Q9UCP5; Q9UDE0 [Other Products]
 UniProt Related Accession #    P16112 [Other Products]
 Molecular Weight    250,193 Da
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 NCBI Official Full Name    Aggrecan
 NCBI Official Synonym Full Names    aggrecan
 NCBI Official Symbol    ACAN [Similar Products]
 NCBI Official Synonym Symbols   
AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP
[Similar Products]
 NCBI Protein Information    aggrecan core protein; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1
 UniProt Protein Name    Aggrecan core protein
 UniProt Synonym Protein Names   
Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1
 Protein Family    Aggrecan core protein
 UniProt Gene Name    ACAN [Similar Products]
 UniProt Synonym Gene Names    AGC1; CSPG1; MSK16; CSPCP [Similar Products]
 UniProt Entry Name    PGCA_HUMAN
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 NCBI Summary for AGC    This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AGC    ACAN: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK). Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Defects in ACAN are the cause of spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN). A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Defects in ACAN are the cause of osteochondritis dissecans short stature and early-onset osteoarthritis (OD). It is a type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Belongs to the aggrecan/versican proteoglycan family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function: protein binding; extracellular matrix structural constituent; metal ion binding; hyaluronic acid binding; carbohydrate binding

Biological Process: keratan sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process; proteolysis; cell adhesion; skeletal development

Disease: Spondyloepiphyseal Dysplasia, Kimberley Type; Osteochondritis Dissecans, Short Stature, And Early-onset Osteoarthritis; Spondyloepimetaphyseal Dysplasia, Aggrecan Type
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 Research Articles on AGC    1. aggrecan alleles with shorter VNTR length have a role in intervertebral disc degeneration, while VDR (TaqI, FokI, ApaI) gene polymorphisms do not [meta-analysis]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGC elisa kitPathways associated with AGC elisa kit
 Reference Product  PubMed Publications
 SOX9 elisa kit  >37 publications with AGC and SOX9
 ADAMTS4 elisa kit  >6 publications with AGC and ADAMTS4
 BMP2 elisa kit  >3 publications with AGC and BMP2
 FMOD elisa kit  >3 publications with AGC and FMOD
 LUM elisa kit  >2 publications with AGC and LUM
 KERA elisa kit  >1 publications with AGC and KERA
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
Organs/Tissues associated with AGC elisa kit
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >18 publications with AGC and Connective Tissue
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