Q09328.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
NCBI Official Synonym Full Names
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
NCBI Protein Information
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; glcNAc-T V; N-acetylglucosaminyl-transferase V; mannoside acetylglucosaminyltransferase 5; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase
UniProt Protein Name
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
UniProt Synonym Protein Names
Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; GlcNAc-T V; GNT-V; Mannoside acetylglucosaminyltransferase 5; N-acetylglucosaminyl-transferase V
UniProt Synonym Gene Names
UniProt Entry Name
MGT5A_HUMAN
NCBI Summary for MGAT5
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]
UniProt Comments for MGAT5
MGAT5: Catalyzes the addition of N-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Belongs to the glycosyltransferase 18 family.
Protein type: EC 2.4.1.155; Transferase; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q21.3
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity
Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Research Articles on MGAT5
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Products associated with MGAT5 elisa kit
Pathways associated with MGAT5 elisa kit
Diseases associated with MGAT5 elisa kit
Organs/Tissues associated with MGAT5 elisa kit
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