P52849.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,093 Da
NCBI Official Full Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
NCBI Official Synonym Full Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NCBI Official Synonym Symbols
NCBI Protein Information
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; NDST-2; N-HSST 2; N-heparan sulfate sulfotransferase 2; glucosaminyl N-deacetylase/N-sulfotransferase 2
UniProt Protein Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
UniProt Synonym Protein Names
Glucosaminyl N-deacetylase/N-sulfotransferase 2; NDST-2; N-heparan sulfate sulfotransferase 2; N-HSST 2
UniProt Synonym Gene Names
UniProt Entry Name
NDST2_HUMAN
NCBI Summary for NDST2
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
UniProt Comments for NDST2
NDST2: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.8.2.8; Transferase
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: [heparan sulfate]-glucosamine N-sulfotransferase activity; hydrolase activity
Biological Process: glycosaminoglycan biosynthetic process; heparin biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; heparan sulfate proteoglycan biosynthetic process; pathogenesis
Research Articles on NDST2
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Products associated with NDST2 elisa kit
Pathways associated with NDST2 elisa kit
Diseases associated with NDST2 elisa kit
Organs/Tissues associated with NDST2 elisa kit
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