NP_001789.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,035 Da
NCBI Official Full Name
cyclin-dependent kinase 2 isoform 1
NCBI Official Synonym Full Names
cyclin-dependent kinase 2
NCBI Protein Information
cyclin-dependent kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33 protein kinase
UniProt Protein Name
Cyclin-dependent kinase 2
UniProt Synonym Protein Names
Cell division protein kinase 2; p33 protein kinase
UniProt Synonym Gene Names
UniProt Entry Name
CDK2_HUMAN
NCBI Summary for CDK2
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for CDK2
CDK2: a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276
Protein type: Cell cycle regulation; EC 2.7.11.22; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: Y chromosome; nucleoplasm; Cajal body; centrosome; chromosome, telomeric region; transcription factor complex; X chromosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; condensed chromosome; nucleus; cytosol; endosome
Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; metal ion binding; histone kinase activity; ATP binding
Biological Process: G1 DNA damage checkpoint; meiosis; mitosis; histone phosphorylation; positive regulation of transcription, DNA-dependent; DNA repair; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; peptidyl-serine phosphorylation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; positive regulation of cell proliferation; Ras protein signal transduction; mitotic cell cycle; DNA replication; G2/M transition of mitotic cell cycle; blood coagulation; centrosome duplication; potassium ion transport; G1/S transition of mitotic cell cycle; positive regulation of DNA replication initiation
Research Articles on CDK2
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Products associated with CDK2 elisa kit
Pathways associated with CDK2 elisa kit
Diseases associated with CDK2 elisa kit
Organs/Tissues associated with CDK2 elisa kit
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