NP_955767.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,831 Da
NCBI Official Full Name
collagen alpha-2(VIII) chain
NCBI Official Synonym Full Names
collagen, type VIII, alpha 2
NCBI Official Synonym Symbols
NCBI Protein Information
collagen alpha-2(VIII) chain; collagen alpha-2(VIII) chain; endothelial collagen; procollagen type VIII alpha 2; procollagen, type VIII, alpha 2
UniProt Protein Name
Collagen alpha-2(VIII) chain
UniProt Synonym Protein Names
Endothelial collagen
UniProt Entry Name
CO8A2_MOUSE
UniProt Comments for COL8alpha1
COL8A2: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Defects in COL8A2 are the cause of corneal dystrophy Fuchs endothelial type 1 (FECD1). It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Defects in COL8A2 are the cause of posterior polymorphous corneal dystrophy type 2 (PPCD2). PPCD is a rare bilateral familial disorder of the corneal epithelium, and is inherited in a autosomal dominant pattern. The clinical features usually present earlier than FECD, being from birth onwards. The disorder is characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit- lamp examination and specular microscopy. Affected patient typically are asymptomatic.
Protein type: Extracellular matrix; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen; extracellular region; basement membrane
Biological Process: epithelial cell proliferation; camera-type eye morphogenesis; angiogenesis; cell adhesion
Research Articles on COL8alpha1
Precautions
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Disclaimer
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Pathways associated with COL8alpha1 elisa kit
Diseases associated with COL8alpha1 elisa kit
Disease Name |
Pubmed Publications |
Disease Models, Animal Antibodies |
>9 publications with COL8alpha1 and Disease Models, Animal |
Corneal Dystrophy, Posterior Polymorphous, 2 Antibodies |
>6 publications with COL8alpha1 and Corneal Dystrophy, Posterior Polymorphous, 2 |
Edema Antibodies |
>4 publications with COL8alpha1 and Edema |
Kidney Diseases Antibodies |
>3 publications with COL8alpha1 and Kidney Diseases |
Skin Diseases Antibodies |
>2 publications with COL8alpha1 and Skin Diseases |
Proteinuria Antibodies |
>1 publications with COL8alpha1 and Proteinuria |
Carcinoma, Hepatocellular Antibodies |
>1 publications with COL8alpha1 and Carcinoma, Hepatocellular |
Heart Defects, Congenital Antibodies |
>1 publications with COL8alpha1 and Heart Defects, Congenital |
Corneal Dystrophy, Posterior Polymorphous, 1 Antibodies |
>1 publications with COL8alpha1 and Corneal Dystrophy, Posterior Polymorphous, 1 |
Organs/Tissues associated with COL8alpha1 elisa kit
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