NP_004128.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,858 Da
NCBI Official Full Name
calcium-activated potassium channel subunit beta-1
NCBI Official Synonym Full Names
potassium large conductance calcium-activated channel, subfamily M, beta member 1
NCBI Official Synonym Symbols
hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1 [Similar Products]
NCBI Protein Information
calcium-activated potassium channel subunit beta-1; BK channel subunit beta-1; maxi K channel subunit beta-1; charybdotoxin receptor subunit beta-1; large conductance Ca2+-activated K+ channel beta 1 subunit; calcium-activated potassium channel, subfamily M subunit beta-1
UniProt Protein Name
Calcium-activated potassium channel subunit beta-1
UniProt Synonym Protein Names
BK channel subunit beta-1; BKbeta; BKbeta1; Hbeta1; Calcium-activated potassium channel, subfamily M subunit beta-1; Calcium-activated potassium channel subunit beta; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta
UniProt Synonym Gene Names
BKbeta; BKbeta1; Hbeta1; Calcium-activated potassium channel subunit beta; Slo-beta [Similar Products]
UniProt Entry Name
KCMB1_HUMAN
NCBI Summary for KCNMB1
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNMB1
KCNMB1: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: voltage-gated potassium channel complex; plasma membrane
Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity
Biological Process: synaptic transmission; detection of calcium ion; blood coagulation; potassium ion transport
Disease: Hypertension, Diastolic, Resistance To
Research Articles on KCNMB1
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Products associated with KCNMB1 elisa kit
Pathways associated with KCNMB1 elisa kit
Diseases associated with KCNMB1 elisa kit
Organs/Tissues associated with KCNMB1 elisa kit
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