NP_001159417.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,998 Da
NCBI Official Full Name
chloride channel protein ClC-Kb isoform 2
NCBI Official Synonym Full Names
chloride channel, voltage-sensitive Kb
NCBI Protein Information
chloride channel protein ClC-Kb; chloride channel, kidney, B
UniProt Protein Name
Chloride channel protein ClC-Kb
UniProt Synonym Protein Names
ClC-K2
UniProt Synonym Gene Names
UniProt Entry Name
CLCKB_HUMAN
NCBI Summary for CLCNKB
The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for CLCNKB
CLCNKB: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKB are the cause of Bartter syndrome type 3 (BS3); also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels. Defects in CLCNKB are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: metal ion binding; voltage-gated chloride channel activity
Biological Process: transport; excretion; transmembrane transport
Disease: Bartter Syndrome, Type 4b; Bartter Syndrome, Type 3
Research Articles on CLCNKB
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Products associated with CLCNKB elisa kit
Pathways associated with CLCNKB elisa kit
Diseases associated with CLCNKB elisa kit
Organs/Tissues associated with CLCNKB elisa kit
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