AAA51985.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,840 Da
NCBI Official Full Name
coagulation factor XI
NCBI Official Synonym Full Names
coagulation factor XI
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor XI; PTA; plasma thromboplastin antecedent
UniProt Protein Name
Coagulation factor XI
UniProt Synonym Protein Names
Plasma thromboplastin antecedent; PTA
UniProt Synonym Gene Names
UniProt Entry Name
FA11_HUMAN
NCBI Summary for F11
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
UniProt Comments for F11
F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; EC 3.4.21.27; Secreted; Protease
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: extracellular space; membrane; plasma membrane; extracellular region
Molecular Function: heparin binding; protein binding; serine-type endopeptidase activity
Biological Process: positive regulation of fibrinolysis; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation
Disease: Factor Xi Deficiency
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Pathways associated with F11 elisa kit
Diseases associated with F11 elisa kit
Organs/Tissues associated with F11 elisa kit
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