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CFL2 elisa kit :: Monkey Cofilin 2, Muscle ELISA Kit

Scan QR to view Datasheet Catalog #    MBS024411
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cofilin 2, Muscle (CFL2), ELISA Kit

 Also Known As   

Monkey Cofilin 2, Muscle ELISA Kit

 Product Gene Name   

CFL2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 Chromosome Location    Chromosome: 14; NC_000014.8 (35179588..35184029, complement). Location: 14q12
 OMIM    601443
 3D Structure    ModBase 3D Structure for Q9Y281
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 Species Reactivity    Monkey
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 Specificity    No significant cross-reactivity or interference between Monkey CFL2 and analogues was observed.
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 Samples    Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids
 Assay Type    Sandwich
 Detection Range    31.2 pg/ml - 1000 pg/ml.
 Sensitivity    5.0 pg/ml.
 Intended Uses    ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This Quantitative Sandwich ELISA kit is in tended to determinate CFL2 concentrations in Monkey serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of CFL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CFL2 purchase    MBS024411 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cofilin 2, Muscle (CFL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2 pg/ml - 1000 pg/ml in biological research samples containing CFL2, with an estimated sensitivity of 5.0 pg/ml. The ELISA analytical biochemical technique of the MBS024411 kit is based on CFL2 antibody-CFL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CFL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CFL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for CFL2 elisa kit

   Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This Quantitative Sandwich ELISA kit is in tended to determinate CFL2 concentrations in Monkey serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!
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 Typical Testing Data/Standard Curve (for reference only) of CFL2 elisa kit    CFL2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS024411
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NCBI/Uniprot data below describe general gene information for CFL2. It may not necessarily be applicable to this product.
 NCBI GI #    343887344
 NCBI GeneID    1073
 NCBI Accession #    NP_001230574.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243645.1 [Other Products]
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 UniProt Primary Accession #    Q9Y281 [Other Products]
 UniProt Secondary Accession #    G3V5P4 [Other Products]
 UniProt Related Accession #    Q9Y281 [Other Products]
 Molecular Weight    18,737 Da
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 NCBI Official Full Name    cofilin-2 isoform 2
 NCBI Official Synonym Full Names    cofilin 2 (muscle)
 NCBI Official Symbol    CFL2 [Similar Products]
 NCBI Official Synonym Symbols   
NEM7
[Similar Products]
 NCBI Protein Information    cofilin-2; cofilin, muscle isoform; nemaline myopathy type 7
 UniProt Protein Name    Cofilin-2
 UniProt Synonym Protein Names   
Cofilin, muscle isoform
 Protein Family    Cofilin
 UniProt Gene Name    CFL2 [Similar Products]
 UniProt Entry Name    COF2_HUMAN
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 NCBI Summary for CFL2    This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
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 UniProt Comments for CFL2    Cofilin-2: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.

Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: I band; extracellular space; nuclear matrix; actin cytoskeleton

Molecular Function: protein binding; actin binding

Biological Process: muscle maintenance; actin filament depolymerization; positive regulation of actin filament depolymerization; sarcomere organization

Disease: Nemaline Myopathy 7
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 Research Articles on CFL2    1. Studies indicate that cofilin binds actin stoichiometrically - one cofilin molecule per actin filament subunit.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CFL2 elisa kitPathways associated with CFL2 elisa kit
 Reference Product  PubMed Publications
 LIMK1 elisa kit  >2 publications with CFL2 and LIMK1
 RHOA elisa kit  >1 publications with CFL2 and RHOA
 LIMK2 elisa kit  >1 publications with CFL2 and LIMK2
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
Diseases associated with CFL2 elisa kitOrgans/Tissues associated with CFL2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with CFL2 and Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with CFL2 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >2 publications with CFL2 and Disease Models, Animal
 Nemaline Myopathy 7 Antibodies  >2 publications with CFL2 and Nemaline Myopathy 7
 Nervous System Malformations Antibodies  >1 publications with CFL2 and Nervous System Malformations
 Carcinoma Antibodies  >1 publications with CFL2 and Carcinoma
 Neural Tube Defects Antibodies  >1 publications with CFL2 and Neural Tube Defects
 Adenocarcinoma Antibodies  >1 publications with CFL2 and Adenocarcinoma
 Hyperplasia Antibodies  >1 publications with CFL2 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >19 publications with CFL2 and Muscle
 Blood Antibodies  >3 publications with CFL2 and Blood
 Vascular Antibodies  >3 publications with CFL2 and Vascular
 Heart Antibodies  >3 publications with CFL2 and Heart
 Embryonic Tissue Antibodies  >2 publications with CFL2 and Embryonic Tissue
 Adipose Tissue Antibodies  >1 publications with CFL2 and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with CFL2 and Connective Tissue
 Testis Antibodies  >1 publications with CFL2 and Testis
 Kidney Antibodies  >1 publications with CFL2 and Kidney
 Brain Antibodies  >1 publications with CFL2 and Brain
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