NP_057075.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,017 Da
NCBI Official Full Name
complement C1q subcomponent subunit A
NCBI Official Synonym Full Names
complement component 1, q subcomponent, A chain
NCBI Protein Information
complement C1q subcomponent subunit A; complement component C1q, A chain; complement component 1, q subcomponent, alpha polypeptide
UniProt Protein Name
Complement C1q subcomponent subunit A
UniProt Entry Name
C1QA_HUMAN
NCBI Summary for C1QA
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]
UniProt Comments for C1QA
C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: collagen; extracellular region; complement component C1 complex
Molecular Function: protein binding
Biological Process: cell-cell signaling; innate immune response; complement activation, classical pathway; complement activation
Disease: C1q Deficiency
Research Articles on C1QA
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Products associated with C1QA elisa kit
Pathways associated with C1QA elisa kit
Diseases associated with C1QA elisa kit
Organs/Tissues associated with C1QA elisa kit
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